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Literature DB >> 20113853

Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: aflatoxin B1 (AFB1).

Diane Benford¹, Jean-Charles Leblanc, R Woodrow Setzer.

Abstract

Aflatoxin B1 (AFB1) has been consistently shown to be a potent mutagen and is a liver carcinogen in humans and a wide range of animal species. The Fisher rat appears to be the most sensitive animal model. Dose-response modelling results in a BMDL(10) of 250 ng/kg-bw/d. Estimates of mean dietary exposure estimates were 0.4 ng/kg-bw/d and 2.6 ng/kg-bw/d, representing regions with low and high exposure, respectively. The MOEs for mean exposure therefore range from 100 to 600. Crown Copyright 2010. Published by Elsevier Ltd. All rights reserved.

Entities: Chemical Disease Species

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Year: 2010 PMID： 20113853 DOI： 10.1016/j.fct.2009.10.037

Source DB: PubMed Journal: Food Chem Toxicol ISSN： 0278-6915 Impact factor: 6.023

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Cited

11 in total

Review 1. Mode of action-based risk assessment of genotoxic carcinogens.

Authors: Andrea Hartwig; Michael Arand; Bernd Epe; Sabine Guth; Gunnar Jahnke; Alfonso Lampen; Hans-Jörg Martus; Bernhard Monien; Ivonne M C M Rietjens; Simone Schmitz-Spanke; Gerlinde Schriever-Schwemmer; Pablo Steinberg; Gerhard Eisenbrand
Journal: Arch Toxicol Date: 2020-06-15 Impact factor: 5.153

2. A preliminary study on aflatoxin exposure by urine biomonitoring in Chile.

Authors: Claudia Foerster; Liliam Monsalve; Carlos Maldonado; Sandra Cortés; Catterina Ferreccio
Journal: Mycotoxin Res Date: 2022-05-31 Impact factor: 4.082

3. Aflatoxins in peanut butter in Khartoum State, Sudan.

Authors: Amin Osman Elzupir; Amar O A Salih; Suliman A Suliman; Ali A Adam; Abdelrahim M Elhussein
Journal: Mycotoxin Res Date: 2011-04-20 Impact factor: 3.833

4. Exposure assessment and risk characterization of aflatoxin B1 in Malaysia.

Authors: Yin-Hui Leong; Ahmad Rosma; Aishah A Latiff; Nurul Izzah Ahmad
Journal: Mycotoxin Res Date: 2011-05-11 Impact factor: 3.833

5. Histological lesions, cell cycle arrest, apoptosis and T cell subsets changes of spleen in chicken fed aflatoxin-contaminated corn.

Authors: Xi Peng; Keying Zhang; Shiping Bai; Xuemei Ding; Qiufeng Zeng; Jun Yang; Jing Fang; Kejie Chen
Journal: Int J Environ Res Public Health Date: 2014-08-20 Impact factor: 3.390

Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: aflatoxin B1 (AFB1).

Review 1. Mode of action-based risk assessment of genotoxic carcinogens.

2. A preliminary study on aflatoxin exposure by urine biomonitoring in Chile.

3. Aflatoxins in peanut butter in Khartoum State, Sudan.

4. Exposure assessment and risk characterization of aflatoxin B1 in Malaysia.

5. Histological lesions, cell cycle arrest, apoptosis and T cell subsets changes of spleen in chicken fed aflatoxin-contaminated corn.

6. A Risk-Based Strategy for Evaluating Mitigation Options for Process-Formed Compounds in Food: Workshop Proceedings.

7. Probabilistic risk assessment of dietary exposure to aflatoxin B₁ in Guangzhou, China.

8. Estimated dietary exposure to mycotoxins after taking into account the cooking of staple foods in Japan.

Review 9. Mycotoxins in Tea: Occurrence, Methods of Determination and Risk Evaluation.

10. Dietary exposure of the Qatari population to food mycotoxins and reflections on the regulation limits.