Literature DB >> 20111901

SSeCKS promotes tumor necrosis factor-alpha autocrine via activating p38 and JNK pathways in Schwann cells.

Zhengming Zhou1, Tao Tao, Yuhong Ji, Huiguang Yang, Youhua Wang, Chun Cheng, Aiguo Shen, Xiang Lu.   

Abstract

Tumor necrosis factor-alpha (TNF-alpha) derived from activated Schwann cells (SCs) plays a critical role as an inflammatory mediator in the peripheral nervous system disease. TNF-alpha could act as an autocrine mediator in SC activation. In this study, we found knockdown Src-suppressed protein kinase C substrate (SSeCKS) expression suppressed TNF-alpha production induced by TNF-alpha, overexpression of SSeCKS could promoted TNF-alpha autocrine in SCs. Such effects might be resulted in SSeCKS promoted p38 and JNK activation in SCs treated by TNF-alpha. Thus present data show that while SCs activation, SSeCKS may plays an important role in the release of inflammatory mediators.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20111901     DOI： 10.1007/s10571-009-9494-z

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  25 in total

1.  Loss of the SSeCKS/Gravin/AKAP12 gene results in prostatic hyperplasia.

Authors:  Shin Akakura; Changhui Huang; Peter J Nelson; Barbara Foster; Irwin H Gelman
Journal:  Cancer Res       Date:  2008-07-01       Impact factor: 12.701

2.  Calmodulin and cyclin D anchoring sites on the Src-suppressed C kinase substrate, SSeCKS.

Authors:  Xueying Lin; Irwin H Gelman
Journal:  Biochem Biophys Res Commun       Date:  2002-02-08       Impact factor: 3.575

3.  Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras.

Authors:  X Lin; P J Nelson; B Frankfort; E Tombler; R Johnson; I H Gelman
Journal:  Mol Cell Biol       Date:  1995-05       Impact factor: 4.272

4.  Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway.

Authors:  G Natoli; A Costanzo; A Ianni; D J Templeton; J R Woodgett; C Balsano; M Levrero
Journal:  Science       Date:  1997-01-10       Impact factor: 47.728

5.  Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein.

Authors:  J B Nauert; T M Klauck; L K Langeberg; J D Scott
Journal:  Curr Biol       Date:  1997-01-01       Impact factor: 10.834

Review 6.  Schwann cells: activated peripheral glia and their role in neuropathic pain.

Authors:  Wendy Marie Campana
Journal:  Brain Behav Immun       Date:  2007-02-26       Impact factor: 7.217

7.  TNF-alpha as an autocrine mediator and its role in the activation of Schwann cells.

Authors:  Yongwei Qin; Chun Cheng; Haibo Wang; Xiaoyi Shao; Yongjing Gao; Aiguo Shen
Journal:  Neurochem Res       Date:  2008-01-17       Impact factor: 3.996

8.  Tumor necrosis factor-induced proliferation of astrocytes from mature brain is associated with down-regulation of glial fibrillary acidic protein mRNA.

Authors:  K Selmaj; B Shafit-Zagardo; D A Aquino; M Farooq; C S Raine; W T Norton; C F Brosnan
Journal:  J Neurochem       Date:  1991-09       Impact factor: 5.372

9.  Chronic glial activation, neurodegeneration, and APP immunoreactive deposits following acute administration of double-stranded RNA.

Authors:  Lisa M Melton; Alexander B Keith; Sue Davis; Arthur E Oakley; James A Edwardson; Christopher M Morris
Journal:  Glia       Date:  2003-10       Impact factor: 7.452

10.  Involvement of the protein kinase C substrate, SSeCKS, in the actin-based stellate morphology of mesangial cells.

Authors:  P J Nelson; K Moissoglu; J Vargas; P E Klotman; I H Gelman
Journal:  J Cell Sci       Date:  1999-02       Impact factor: 5.285
View more
  3 in total

1.  Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma.

Authors:  Haifeng Wang; Jiansong Wang; Yigang Zuo; Mingxia Ding; Ruping Yan; Delin Yang; Changxin Ke
Journal:  Med Oncol       Date:  2011-07-14       Impact factor: 3.064

2.  The relationship between Src-suppressed C kinase substrate and β-1,4 galactosyltransferase-I in the process of lipopolysaccharide-induced TNF-α secretion in rat primary astrocytes.

Authors:  Bai Shao; Chunmiao Li; Huiguang Yang; Aiguo Shen; Xiaohong Wu; Qin Yuan; Xiujie Wu; Lihua Kang; Zhiqiang Liu; Guowei Zhang; Xiang Lu; Chun Cheng
Journal:  Cell Mol Neurobiol       Date:  2011-05-14       Impact factor: 5.046

3.  β-1,4-galactosyltransferase I promotes tumor necrosis factor-α autocrine via the activation of MAP kinase signal pathways in Schwann cells.

Authors:  Huiguang Yang; Qin Yuan; Qian Chen; Chunmiao Li; Xiujie Wu; Chen Peng; Lihua Kang; Xiang Lu; Huiqing Sun; Zhengming Zhou; Aiguo Shen; Chun Cheng
Journal:  J Mol Neurosci       Date:  2011-04-02       Impact factor: 3.444
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.