Literature DB >> 20111051

Hyponatremia and seizures caused by triamcinolone-induced adrenal insufficiency.

Stefan Reuter1, Niklas Scholten, Hermann Pavenstädt, Uta Hillebrand, Eckhart Büssemaker.   

Abstract

BACKGROUND: A 49-year-old woman presented to hospital with an 18-month history of hyponatremic episodes, nausea, vomiting, anorexia and fatigue. INVESTIGATIONS: Physical examination, laboratory tests including full blood count, measurement of electrolytes, hormones, autoantibodies, thyroid and renal function, corticotropin-releasing-hormone stimulation test, 24 h urinalysis and abdominal ultrasonography. DIAGNOSIS: Severe symptomatic hyponatremia in a patient with secondary adrenal insufficiency caused by treatment of lumbago with triamcinolone injections. MANAGEMENT: Hydrocortisone replacement therapy (15 mg daily) for 3 months, followed by a tapering schedule over 12-24 months.

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Year:  2010        PMID: 20111051     DOI: 10.1038/nrneph.2009.215

Source DB:  PubMed          Journal:  Nat Rev Nephrol        ISSN: 1759-5061            Impact factor:   28.314


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