BACKGROUND AND AIMS: Vertebral fracture (VF) is the most common complication of osteoporosis. However, more than half of all VF are asymptomatic and may go unnoticed, even in patients with osteoporosis. Our aim was to assess the prevalence of VF in postmenopausal women with osteopenic lumbar densitometry by means of vertebral morphometry, using the MorphoXpress® software. PATIENTS AND METHODS: This was an epidemiological, cross-sectional, multicenter study conducted among 289 postmenopausal women (>1 year of amenorrhoea), diagnosed with lumbar osteopenia (not due to chronic treatment with corticosteroids or immobilization). Vertebral deformities ≥20% were considered as VF. RESULTS: Demographic and clinical characteristics showed mean age (±SD) 64±9 years, body mass index 27±5 kg/m2, and time from diagnosis of 2±3 years. A total of 25% of subjects had a family history of osteoporotic fracture in first-degree relatives, and 23% had previous fragility fracture. The prevalence of VF was 50% (CI 95% 44-56), the most frequent being the dorsal wedge (34%). Previous fragility fracture was a risk factor for VF (OR 3.13, p=0.0004). A total of 76.5% of patients were receiving treatment, mainly calcium and vitamin D supplements (70%) and bisphosphonates (27%). CONCLUSIONS: MorphoXpress® revealed that 50% of postmenopausal women with osteopenic lumbar densitometry showed VF. This result is important since only 7% of all evaluated subjects had previously been diagnosed with VF.
BACKGROUND AND AIMS: Vertebral fracture (VF) is the most common complication of osteoporosis. However, more than half of all VF are asymptomatic and may go unnoticed, even in patients with osteoporosis. Our aim was to assess the prevalence of VF in postmenopausal women with osteopenic lumbar densitometry by means of vertebral morphometry, using the MorphoXpress® software. PATIENTS AND METHODS: This was an epidemiological, cross-sectional, multicenter study conducted among 289 postmenopausal women (>1 year of amenorrhoea), diagnosed with lumbar osteopenia (not due to chronic treatment with corticosteroids or immobilization). Vertebral deformities ≥20% were considered as VF. RESULTS: Demographic and clinical characteristics showed mean age (±SD) 64±9 years, body mass index 27±5 kg/m2, and time from diagnosis of 2±3 years. A total of 25% of subjects had a family history of osteoporotic fracture in first-degree relatives, and 23% had previous fragility fracture. The prevalence of VF was 50% (CI 95% 44-56), the most frequent being the dorsal wedge (34%). Previous fragility fracture was a risk factor for VF (OR 3.13, p=0.0004). A total of 76.5% of patients were receiving treatment, mainly calcium and vitamin D supplements (70%) and bisphosphonates (27%). CONCLUSIONS: MorphoXpress® revealed that 50% of postmenopausal women with osteopenic lumbar densitometry showed VF. This result is important since only 7% of all evaluated subjects had previously been diagnosed with VF.
Authors: M Fusaro; G Crepaldi; S Maggi; F Galli; A D'Angelo; L Calò; S Giannini; D Miozzo; M Gallieni Journal: J Endocrinol Invest Date: 2010-11-16 Impact factor: 4.256
Authors: Maria Fusaro; Giovanni Tripepi; Mario Plebani; Cristina Politi; Andrea Aghi; Fulvia Taddei; Enrico Schileo; Martina Zaninotto; Gaetano La Manna; Giuseppe Cianciolo; Maurizio Gallieni; Laura Cosmai; Piergiorgio Messa; Maura Ravera; Thomas L Nickolas; Serge Ferrari; Markus Ketteler; Giorgio Iervasi; Maria Cristina Mereu; Roberto Vettor; Sandro Giannini; Lorenzo Gasperoni; Stefania Sella; Maria Luisa Brandi; Luisella Cianferotti; Raffaele De Caterina Journal: Nutrients Date: 2021-10-12 Impact factor: 5.717