| Literature DB >> 20109966 |
Yung-Li Yang1, Shu-Rung Lin, Jiann-Shiuh Chen, Shu-Wha Lin, Sung-Liang Yu, Hsuan-Yu Chen, Ching-Tzu Yen, Chien-Yu Lin, Jing-Fang Lin, Kai-Hsin Lin, Shiann-Tarng Jou, Chung-Yi Hu, Sheng-Kai Chang, Meng-Yao Lu, Hsiu-Hao Chang, Wan-Hui Chang, Kuo-Sin Lin, Dong-Tsamn Lin.
Abstract
Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that are able to predict treatment response and clinical outcome. The development of impaired apoptosis in leukemic cells is one factor that may influence their response to treatment. We investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan. Univariant analysis revealed that high expression of BCL2L13 was associated with inferior event-free survival and overall survival (p<0.001 and 0.005, respectively). Multivariate analysis for EFS and OS demonstrated that high expression of BCL2L13 was an independent prognostic factor for childhood ALL in this ethnic group. 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20109966 DOI： 10.1016/j.leukres.2009.07.023
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156