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Literature DB >> 20109569

Microtubule motors in eukaryotic spindle assembly and maintenance.

Abstract

The spindle is a microtubule-based structure that facilitates chromosome segregation during mitosis and meiosis. Spindle assembly from dynamic microtubule building blocks is a major challenge for the dividing cell and a process that critically requires microtubule motors. In this review we focus on the mechanisms by which microtubule motors shape the spindle. Specifically, we address how motors are thought to move and arrange microtubules to form the characteristic bipolar morphology shared by all eukaryotic spindles as well as motor-dependent mechanisms of microtubule length regulation. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year: 2010 PMID： 20109569 PMCID： PMC2927864 DOI： 10.1016/j.semcdb.2010.01.015

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

83 in total

1. MCAK associates with EB1.

Authors: T Lee; K J Langford; J M Askham; A Brüning-Richardson; E E Morrison
Journal: Oncogene Date: 2007-10-29 Impact factor: 9.867

Review 2. Mechanisms of mitotic spindle assembly and function.

Authors: Claire E Walczak; Rebecca Heald
Journal: Int Rev Cytol Date: 2008

3. The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment.

Authors: Jason Stumpff; George von Dassow; Michael Wagenbach; Charles Asbury; Linda Wordeman
Journal: Dev Cell Date: 2008-02 Impact factor: 12.270

4. Minus-end-directed motor Ncd exhibits processive movement that is enhanced by microtubule bundling in vitro.

Authors: Ken'ya Furuta; Yoko Yano Toyoshima
Journal: Curr Biol Date: 2008-01-22 Impact factor: 10.834

5. Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly.

Authors: Marvin E Tanenbaum; Libor Macůrek; Niels Galjart; René H Medema
Journal: EMBO J Date: 2008-11-20 Impact factor: 11.598

6. Chromosome congression by Kinesin-5 motor-mediated disassembly of longer kinetochore microtubules.

Authors: Melissa K Gardner; David C Bouck; Leocadia V Paliulis; Janet B Meehl; Eileen T O'Toole; Julian Haase; Adelheid Soubry; Ajit P Joglekar; Mark Winey; Edward D Salmon; Kerry Bloom; David J Odde
Journal: Cell Date: 2008-11-28 Impact factor: 41.582

7. Detection of GTP-tubulin conformation in vivo reveals a role for GTP remnants in microtubule rescues.

Authors: Ariane Dimitrov; Mélanie Quesnoit; Sandrine Moutel; Isabelle Cantaloube; Christian Poüs; Franck Perez
Journal: Science Date: 2008-10-16 Impact factor: 47.728

8. Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle.

Authors: Ge Yang; Lisa A Cameron; Paul S Maddox; Edward D Salmon; Gaudenz Danuser
Journal: J Cell Biol Date: 2008-08-18 Impact factor: 10.539

9. Poleward transport of Eg5 by dynein-dynactin in Xenopus laevis egg extract spindles.

Authors: Marianne Uteng; Christian Hentrich; Kota Miura; Peter Bieling; Thomas Surrey
Journal: J Cell Biol Date: 2008-08-18 Impact factor: 10.539

10. Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle.

Authors: Gohta Goshima; Mirjam Mayer; Nan Zhang; Nico Stuurman; Ronald D Vale
Journal: J Cell Biol Date: 2008-04-28 Impact factor: 10.539

29 in total

Review 1. Biophysics of mitosis.

Authors: J Richard McIntosh; Maxim I Molodtsov; Fazly I Ataullakhanov
Journal: Q Rev Biophys Date: 2012-02-10 Impact factor: 5.318

Microtubule motors in eukaryotic spindle assembly and maintenance.

1. MCAK associates with EB1.

Review 2. Mechanisms of mitotic spindle assembly and function.

3. The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment.

4. Minus-end-directed motor Ncd exhibits processive movement that is enhanced by microtubule bundling in vitro.

5. Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly.

6. Chromosome congression by Kinesin-5 motor-mediated disassembly of longer kinetochore microtubules.

7. Detection of GTP-tubulin conformation in vivo reveals a role for GTP remnants in microtubule rescues.

8. Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle.

9. Poleward transport of Eg5 by dynein-dynactin in Xenopus laevis egg extract spindles.

10. Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle.

Review 1. Biophysics of mitosis.

Review 2. Towards a quantitative understanding of mitotic spindle assembly and mechanics.

Review 3. Unconventional functions of microtubule motors.

Review 4. The dynamic cytoskeleton of the developing male germ cell.

5. Tau-based fluorescent protein fusions to visualize microtubules.

6. XMAP215 activity sets spindle length by controlling the total mass of spindle microtubules.

Review 7. Targeting Microtubules for Wound Repair.

8. Microtubule dynamics alter the interphase nucleus.

Review 9. Regulation of the cell division cycle in Trypanosoma brucei.

10. Spindly/CCDC99 is required for efficient chromosome congression and mitotic checkpoint regulation.