BACKGROUND AND AIM: The major groups of phytonutrients found in plants include polyphenols, flavonoids, terpenes, amines, etc., all of which are observed to have potential anti-allergic activity. In this study, we evaluated the anti-allergic activity of the standardized extract of Albizia lebbeck with respect to the catechin, a polyphenolic phytomarker. MATERIAL AND METHODS: The percentage of catechin in the ethanolic extract was found to be 14.72 mg/g. We administered Albizia lebbeck (50-300 mg/kg) and 50 mg/kg of catechin to mice to evaluate the mast cell stabilization and estimation of histamine elevation in the plasma. RESULTS AND CONCLUSION: Results support the conclusion that Albizia lebbeck at different concentrations has got potent mast cell stabilizing property and the IC(50) value of Albizia lebbeck was found to be 85 microg/ml. This inhibitory potential of catechin from Albizia lebbeck is perhaps due to modulation of two important effector's functions, histamine release and cytokine expression of antigen -IgE activated mast cells.
BACKGROUND AND AIM: The major groups of phytonutrients found in plants include polyphenols, flavonoids, terpenes, amines, etc., all of which are observed to have potential anti-allergic activity. In this study, we evaluated the anti-allergic activity of the standardized extract of Albizia lebbeck with respect to the catechin, a polyphenolic phytomarker. MATERIAL AND METHODS: The percentage of catechin in the ethanolic extract was found to be 14.72 mg/g. We administered Albizia lebbeck (50-300 mg/kg) and 50 mg/kg of catechin to mice to evaluate the mast cell stabilization and estimation of histamine elevation in the plasma. RESULTS AND CONCLUSION: Results support the conclusion that Albizia lebbeck at different concentrations has got potent mast cell stabilizing property and the IC(50) value of Albizia lebbeck was found to be 85 microg/ml. This inhibitory potential of catechin from Albizia lebbeck is perhaps due to modulation of two important effector's functions, histamine release and cytokine expression of antigen -IgE activated mast cells.
Authors: Garima Singh; Ajit K Passsari; Vincent V Leo; Vineet K Mishra; Sarathbabu Subbarayan; Bhim P Singh; Brijesh Kumar; Sunil Kumar; Vijai K Gupta; Hauzel Lalhlenmawia; Senthil K Nachimuthu Journal: Front Plant Sci Date: 2016-03-31 Impact factor: 5.753
Authors: Mohammed S Hifnawy; Mahmoud A Aboseada; Hossam M Hassan; Asmaa M AboulMagd; Adel F Tohamy; Samraa H Abdel-Kawi; Mostafa E Rateb; El Moataz Bellah El Naggar; Miaomiao Liu; Ronald J Quinn; Hani A Alhadrami; Usama Ramadan Abdelmohsen Journal: Metabolites Date: 2020-01-11