BACKGROUND/AIMS: Publications on etiology of chronic pancreatitis (CP) are infrequent. Etiologies today encompass genetic disorders. We wanted to describe etiologies of today and identify patients with genetic disorders like hereditary pancreatitis (HP), mutations in Serine Protease Inhibitor Kazal type1 (SPINK1), and the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) among patients formerly considered to have idiopathic CP. METHODS: Data on patients diagnosed with first-time CP < 30 years of age in Denmark identified in the Danish National Registry of Patients were retrieved. Patients previously considered to have idiopathic pancreatitis were offered genetic counseling and evaluation for HP, SPINK1, and CFTR mutations. RESULTS: In the period 1980-2004, 580 patients < 30 years of age presented with CP, the standardized prevalence ratio of CP increased from 11.7 per 100,000 person years in 1980-1984 to 17.0 per 100,000 in 2000-2004 (p < 0.001). The odds ratio (OR) having gallstone-related CP increased in the latter time period, especially in women, that of alcohol-induced CP decreased over time. OR having idiopathic CP increased in the latter period; 50% of patients with idiopathic pancreatitis accepted genetic reevaluation; 28 patients had a genetic mutation that totally or partly could explain their pancreatitis, nine of these had two, and 11 patients had HP. CONCLUSION: The prevalence of CP, especially in women, increased over time. Genetic causes that partly or totally could explain the CP were found in 54.90% (95% CI (40.45-68.62)) of those with idiopathic CP, as a minimum estimation 1.9% (95% CI (1.00-3.47)) of the total cohort had HP.
BACKGROUND/AIMS: Publications on etiology of chronic pancreatitis (CP) are infrequent. Etiologies today encompass genetic disorders. We wanted to describe etiologies of today and identify patients with genetic disorders like hereditary pancreatitis (HP), mutations in Serine Protease Inhibitor Kazal type1 (SPINK1), and the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) among patients formerly considered to have idiopathic CP. METHODS: Data on patients diagnosed with first-time CP < 30 years of age in Denmark identified in the Danish National Registry of Patients were retrieved. Patients previously considered to have idiopathic pancreatitis were offered genetic counseling and evaluation for HP, SPINK1, and CFTR mutations. RESULTS: In the period 1980-2004, 580 patients < 30 years of age presented with CP, the standardized prevalence ratio of CP increased from 11.7 per 100,000 person years in 1980-1984 to 17.0 per 100,000 in 2000-2004 (p < 0.001). The odds ratio (OR) having gallstone-related CP increased in the latter time period, especially in women, that of alcohol-induced CP decreased over time. OR having idiopathic CP increased in the latter period; 50% of patients with idiopathic pancreatitis accepted genetic reevaluation; 28 patients had a genetic mutation that totally or partly could explain their pancreatitis, nine of these had two, and 11 patients had HP. CONCLUSION: The prevalence of CP, especially in women, increased over time. Genetic causes that partly or totally could explain the CP were found in 54.90% (95% CI (40.45-68.62)) of those with idiopathic CP, as a minimum estimation 1.9% (95% CI (1.00-3.47)) of the total cohort had HP.
Authors: P Díte; K Starý; I Novotný; M Precechtelová; J Dolina; J Lata; V Zboril Journal: Eur J Gastroenterol Hepatol Date: 2001-06 Impact factor: 2.566
Authors: Randall E Brand; Markus M Lerch; Wendy S Rubinstein; John P Neoptolemos; David C Whitcomb; Ralph H Hruban; Teresa A Brentnall; Henry T Lynch; Marcia I Canto Journal: Gut Date: 2007-10 Impact factor: 23.059
Authors: D C Whitcomb; R A Preston; C E Aston; M J Sossenheimer; P S Barua; Y Zhang; A Wong-Chong; G J White; P G Wood; L K Gates; C Ulrich; S P Martin; J C Post; G D Ehrlich Journal: Gastroenterology Date: 1996-06 Impact factor: 22.682
Authors: W J Coyle; B C Pineau; P R Tarnasky; W L Knapple; L Aabakken; B J Hoffman; J T Cunningham; R H Hawes; P B Cotton Journal: Endoscopy Date: 2002-08 Impact factor: 10.093
Authors: Veronique D Morinville; Sohail Z Husain; Harrison Bai; Bradley Barth; Rabea Alhosh; Peter R Durie; Steven D Freedman; Ryan Himes; Mark E Lowe; John Pohl; Steven Werlin; Michael Wilschanski; Aliye Uc Journal: J Pediatr Gastroenterol Nutr Date: 2012-09 Impact factor: 2.839
Authors: Sarah J Schwarzenberg; Aliye Uc; Bridget Zimmerman; Michael Wilschanski; C Mel Wilcox; David C Whitcomb; Steven L Werlin; David Troendle; Gong Tang; Adam Slivka; Vikesh K Singh; Stuart Sherman; Uzma Shah; Bimaljit S Sandhu; Joseph Romagnuolo; Sue Rhee; John F Pohl; Emily R Perito; Chee Y Ooi; Jaimie D Nathan; Thiruvengadam Muniraj; Veronique D Morinville; Brian McFerron; Maria Mascarenhas; Asim Maqbool; Quin Liu; Tom K Lin; Michele Lewis; Sohail Z Husain; Ryan Himes; Melvin B Heyman; Nalini Guda; Tanja Gonska; Matthew J Giefer; Andres Gelrud; Cheryl E Gariepy; Timothy B Gardner; Steven D Freedman; Christopher E Forsmark; Douglas S Fishman; Gregory A Cote; Darwin Conwell; Randall E Brand; Melena Bellin; Bradley Barth; Peter A Banks; Michelle A Anderson; Stephen T Amann; Samer Alkaade; Maisam Abu-El-Haija; Judah N Abberbock; Mark E Lowe; Dhiraj Yadav Journal: J Pediatr Gastroenterol Nutr Date: 2019-04 Impact factor: 2.839
Authors: Sinead N Duggan; Hazel M Ní Chonchubhair; Oladapo Lawal; Donal B O'Connor; Kevin C Conlon Journal: World J Gastroenterol Date: 2016-02-21 Impact factor: 5.742