Literature DB >> 20107626

Aqueous Compatible Fullerene-Doxorubicin Conjugates.

Fushen Lu1, Sk Anwarul Haque, Sheng-Tao Yang, Pengju G Luo, Lingrong Gu, Alex Kitaygorodskiy, Huaping Li, Sebastian Lacher, Ya-Ping Sun.   

Abstract

Covalent conjugates of fullerene C(60) and the highly effective anticancer drug doxorubicin (DOX) were prepared and studied. The conjugation was through the amide linkage to preserve the intrinsic properties of DOX and fullerene cage. As designed, the conjugates with hydrophilic ethylene glycol spacers exhibited much improved aqueous compatibility, with significant solubility in water-DMSO mixtures. The anti-neoplastic activities of DOX were apparently unaffected in the conjugates according to evaluations in vitro with a human breast cancer cell line.

Entities:  

Year:  2009        PMID： 20107626      PMCID： PMC2811372          DOI： 10.1021/jp906750z

Source DB:  PubMed          Journal:  J Phys Chem C Nanomater Interfaces        ISSN： 1932-7447            Impact factor:   4.126


  22 in total

1.  An extremely effective DNA photocleavage utilizing functionalized liposomes with a fullerene-enriched lipid bilayer.

Authors:  Atsushi Ikeda; Yuki Doi; Mineo Hashizume; Jun-Ichi Kikuchi; Toshifumi Konishi
Journal:  J Am Chem Soc       Date:  2007-03-20       Impact factor: 15.419

2.  Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics.

Authors:  Hanene Ali-Boucetta; Khuloud T Al-Jamal; David McCarthy; Maurizio Prato; Alberto Bianco; Kostas Kostarelos
Journal:  Chem Commun (Camb)       Date:  2007-11-14       Impact factor: 6.222

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Journal:  Bioorg Med Chem       Date:  1996-06       Impact factor: 3.641

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Authors:  E Bakina; Z Wu; M Rosenblum; D Farquhar
Journal:  J Med Chem       Date:  1997-12-05       Impact factor: 7.446

5.  C60-Fullerene monomalonate adducts selectively inactivate neuronal nitric oxide synthase by uncoupling the formation of reactive oxygen intermediates from nitric oxide production.

Authors:  D J Wolff; K Mialkowski; C F Richardson; S R Wilson
Journal:  Biochemistry       Date:  2001-01-09       Impact factor: 3.162

Review 6.  A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.

Authors:  D A Gewirtz
Journal:  Biochem Pharmacol       Date:  1999-04-01       Impact factor: 5.858

Review 7.  Recent advances in protection against doxorubicin-induced toxicity.

Authors:  R Injac; B Strukelj
Journal:  Technol Cancer Res Treat       Date:  2008-12

8.  Active nanodiamond hydrogels for chemotherapeutic delivery.

Authors:  Houjin Huang; Erik Pierstorff; Eiji Osawa; Dean Ho
Journal:  Nano Lett       Date:  2007-10-05       Impact factor: 11.189

9.  Self-assembled nanoparticles based on hydrophobically modified chitosan as carriers for doxorubicin.

Authors:  Jing Zhang; Xi Guang Chen; Yan Yan Li; Cheng Sheng Liu
Journal:  Nanomedicine       Date:  2007-10-24       Impact factor: 5.307

10.  Doxorubicin analogues incorporating chemically reactive substituents.

Authors:  D Farquhar; R A Newman; J E Zuckerman; B S Andersson
Journal:  J Med Chem       Date:  1991-02       Impact factor: 7.446
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  8 in total

1.  Synthesis and evaluation of anticancer activity in cells of novel stoichiometric pegylated fullerene-doxorubicin conjugates.

Authors:  George E Magoulas; Marina Bantzi; Danai Messari; Efstathia Voulgari; Chrisostomi Gialeli; Despoina Barbouri; Athanassios Giannis; Nikos K Karamanos; Dionissios Papaioannou; Konstantinos Avgoustakis
Journal:  Pharm Res       Date:  2014-11-08       Impact factor: 4.200

2.  Supramolecular Assembly of DNA on Graphene Nanoribbons.

Authors:  Darkeyah G Reuven; H B Mihiri Shashikala; Sanjay Mandal; Myron N V Williams; Jaideep Chaudhary; Xiao-Qian Wang
Journal:  J Mater Chem B       Date:  2013-08-28       Impact factor: 6.331

3.  Core-Shell Silver/Polymeric Nanoparticles-Based Combinatorial Therapy against Breast Cancer In-vitro.

Authors:  Nancy M Elbaz; Laila Ziko; Rania Siam; Wael Mamdouh
Journal:  Sci Rep       Date:  2016-08-05       Impact factor: 4.379

4.  Cytotoxic Effects of Dimorfolido-N-Trichloroacetylphosphorylamide and Dimorfolido-N-Benzoylphosphorylamide in Combination with C60 Fullerene on Leukemic Cells and Docking Study of Their Interaction with DNA.

Authors:  S Prylutska; I Grynyuk; A Grebinyk; V Hurmach; Iu Shatrava; T Sliva; V Amirkhanov; Yu Prylutskyy; O Matyshevska; M Slobodyanik; M Frohme; U Ritter
Journal:  Nanoscale Res Lett       Date:  2017-02-17       Impact factor: 4.703

5.  C60 Fullerene Effects on Diphenyl-N-(trichloroacetyl)-amidophosphate Interaction with DNA In Silico and Its Cytotoxic Activity Against Human Leukemic Cell Line In Vitro.

Authors:  A Grebinyk; S Prylutska; I Grynyuk; B Kolp; V Hurmach; T Sliva; V Amirkhanov; V Trush; O Matyshevska; M Slobodyanik; Yu Prylutskyy; M Frohme; U Ritter
Journal:  Nanoscale Res Lett       Date:  2018-03-09       Impact factor: 4.703

6.  Citrate- and Succinate-Modified Carbonate Apatite Nanoparticles with Loaded Doxorubicin Exhibit Potent Anticancer Activity against Breast Cancer Cells.

Authors:  Sultana Mehbuba Hossain; Ezharul Hoque Chowdhury
Journal:  Pharmaceutics       Date:  2018-03-11       Impact factor: 6.321

7.  Effect of C60 on the phase transition behavior of a lipid bilayer under high pressure.

Authors:  Haiyang Yang; Zhiheng Huang; Yong Zhang
Journal:  RSC Adv       Date:  2018-01-02       Impact factor: 4.036

8.  A nanocomplex of C60 fullerene with cisplatin: design, characterization and toxicity.

Authors:  Svitlana Prylutska; Svitlana Politenkova; Kateryna Afanasieva; Volodymyr Korolovych; Kateryna Bogutska; Andriy Sivolob; Larysa Skivka; Maxim Evstigneev; Viktor Kostjukov; Yuriy Prylutskyy; Uwe Ritter
Journal:  Beilstein J Nanotechnol       Date:  2017-07-20       Impact factor: 3.649
  8 in total

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