BACKGROUND: An active lifestyle is associated with a reduced cardiovascular risk in middle-aged as well as in elderly patients. In the present study, we investigated the association between physical activity habits of elderly participants prior to coronary artery bypass grafting (CABG) and survival free from both all-cause and cardiac death. METHODS AND RESULTS: Study population consisted of 587 elderly patients (>or=70 years) CABG patients stratified, according to the Physical Activity Scale for the Elderly (PASE), into less active (low PASE) and exercised (high PASE) groups. At follow-up (mean: 44.3 +/- 21.0 months), 33 (37.1%) of 89 total deaths occurred for cardiac causes. Sixty-month survival rate was 65% and 96% for low-PASE and high-PASE groups, respectively (log rank = 49.460, p < .0001). Cox survival analysis indicated a significant (p < .0001) nonlinear association between PASE score increments and improved survival with the most evident differences in the lowest score categories. A robust association was also found between low PASE score and increased cardiac-related mortality (p < .0001). CONCLUSIONS: Our data indicate that a more active lifestyle is significantly associated with improved survival in elderly CABG patients. The nonlinearity of the relation suggests that more sedentary patients could have the most benefit on survival by increasing their exercise lifestyle habits. The improved outcome is explained by both cardiac and overall mortality reduction.
BACKGROUND: An active lifestyle is associated with a reduced cardiovascular risk in middle-aged as well as in elderly patients. In the present study, we investigated the association between physical activity habits of elderly participants prior to coronary artery bypass grafting (CABG) and survival free from both all-cause and cardiac death. METHODS AND RESULTS: Study population consisted of 587 elderly patients (>or=70 years) CABG patients stratified, according to the Physical Activity Scale for the Elderly (PASE), into less active (low PASE) and exercised (high PASE) groups. At follow-up (mean: 44.3 +/- 21.0 months), 33 (37.1%) of 89 total deaths occurred for cardiac causes. Sixty-month survival rate was 65% and 96% for low-PASE and high-PASE groups, respectively (log rank = 49.460, p < .0001). Cox survival analysis indicated a significant (p < .0001) nonlinear association between PASE score increments and improved survival with the most evident differences in the lowest score categories. A robust association was also found between low PASE score and increased cardiac-related mortality (p < .0001). CONCLUSIONS: Our data indicate that a more active lifestyle is significantly associated with improved survival in elderly CABG patients. The nonlinearity of the relation suggests that more sedentary patients could have the most benefit on survival by increasing their exercise lifestyle habits. The improved outcome is explained by both cardiac and overall mortality reduction.
Authors: Amy M Matteini; M Daniele Fallin; Candace M Kammerer; Nicole Schupf; Anatoli I Yashin; Kaare Christensen; Konstantin G Arbeev; Graham Barr; Richard Mayeux; Anne B Newman; Jeremy D Walston Journal: J Gerontol A Biol Sci Med Sci Date: 2010-09-02 Impact factor: 6.053
Authors: Andrew N Stammers; D Scott Kehler; Jonathan Afilalo; Lorraine J Avery; Sean M Bagshaw; Hilary P Grocott; Jean-Francois Légaré; Sarvesh Logsetty; Colleen Metge; Thang Nguyen; Kenneth Rockwood; Jitender Sareen; Jo-Ann Sawatzky; Navdeep Tangri; Nicholas Giacomantonio; Ansar Hassan; Todd A Duhamel; Rakesh C Arora Journal: BMJ Open Date: 2015-03-09 Impact factor: 2.692
Authors: Nicola W Burton; Zanfina Ademi; Stuart Best; Maria A Fiatarone Singh; Jason S Jenkins; Kenny D Lawson; Anthony S Leicht; Yorgi Mavros; Yian Noble; Paul Norman; Richard Norman; Belinda J Parmenter; Jenna Pinchbeck; Christopher M Reid; Sophie E Rowbotham; Lisan Yip; Jonathan Golledge Journal: BMC Public Health Date: 2016-11-09 Impact factor: 3.295
Authors: D Scott Kehler; Andrew N Stammers; Navdeep Tangri; Brett Hiebert; Randy Fransoo; Annette S H Schultz; Kerry Macdonald; Nicholas Giacomontonio; Ansar Hassan; Jean-Francois Légaré; Rakesh C Arora; Todd A Duhamel Journal: BMJ Open Date: 2017-08-11 Impact factor: 2.692
Authors: Chiara De Biase; Roberta De Rosa; Rossella Luciano; Stefania De Luca; Ernesto Capuano; Bruno Trimarco; Gennaro Galasso Journal: Front Physiol Date: 2014-02-03 Impact factor: 4.566