OBJECTIVES: To identify risk factors for bloodstream infections (BSIs) caused by VIM-1-producing Klebsiella pneumoniae (VPKP). METHODS: Consecutive patients with K. pneumoniae BSIs were identified in three tertiary care hospitals between February 2004 and March 2006. Patients infected with VPKP were designated as cases and those infected with non-VPKP as controls. Potential risk factors for VPKP BSIs were examined by univariate and multivariate analysis. RESULTS: A total of 178 patients with K. pneumoniae BSIs were identified; 67 (37.6%) were infected with VPKP (cases) and 111 with non-VPKP (controls). In multivariate analysis, cases were more likely to have been in an intensive care unit (ICU) [odds ratio (OR), 6.78; 95% confidence interval (CI), 2.69-17.06; P < 0.001], have had prior exposure to >3 different classes of antibiotics (OR, 12.6; 95% CI, 2.17-73.27; P = 0.01) and have had prior use of carbapenems (OR, 2.83; 95% CI, 1.07-7.49; P = 0.03). CONCLUSIONS: Stay in an ICU, prior use of carbapenems and prior exposure to >3 different classes of antibiotics were independent predictors for VPKP BSIs. These findings provide guidance for antibiotic policies and infection control strategies to contain the spread of VPKP.
OBJECTIVES: To identify risk factors for bloodstream infections (BSIs) caused by VIM-1-producing Klebsiella pneumoniae (VPKP). METHODS: Consecutive patients with K. pneumoniae BSIs were identified in three tertiary care hospitals between February 2004 and March 2006. Patients infected with VPKP were designated as cases and those infected with non-VPKP as controls. Potential risk factors for VPKP BSIs were examined by univariate and multivariate analysis. RESULTS: A total of 178 patients with K. pneumoniae BSIs were identified; 67 (37.6%) were infected with VPKP (cases) and 111 with non-VPKP (controls). In multivariate analysis, cases were more likely to have been in an intensive care unit (ICU) [odds ratio (OR), 6.78; 95% confidence interval (CI), 2.69-17.06; P < 0.001], have had prior exposure to >3 different classes of antibiotics (OR, 12.6; 95% CI, 2.17-73.27; P = 0.01) and have had prior use of carbapenems (OR, 2.83; 95% CI, 1.07-7.49; P = 0.03). CONCLUSIONS: Stay in an ICU, prior use of carbapenems and prior exposure to >3 different classes of antibiotics were independent predictors for VPKP BSIs. These findings provide guidance for antibiotic policies and infection control strategies to contain the spread of VPKP.
Authors: G Samonis; E Koutsounaki; D E Karageorgopoulos; P Mitsikostas; C Kalpadaki; V Bozionelou; I Bompolaki; J Sgouros; V Taktikou; M E Falagas Journal: Eur J Clin Microbiol Infect Dis Date: 2011-10-31 Impact factor: 3.267
Authors: M Papadimitriou-Olivgeris; F Fligou; C Bartzavali; A Zotou; A Spyropoulou; K Koutsileou; S Vamvakopoulou; N Sioulas; V Karamouzos; E D Anastassiou; I Spiliopoulou; M Christofidou; M Marangos Journal: Eur J Clin Microbiol Infect Dis Date: 2017-01-19 Impact factor: 3.267
Authors: Giuseppe Migliara; Valentina Baccolini; Claudia Isonne; Sara Cianfanelli; Carolina Di Paolo; Annamaria Mele; Lorenza Lia; Angelo Nardi; Carla Salerno; Susanna Caminada; Vittoria Cammalleri; Francesco Alessandri; Guglielmo Tellan; Giancarlo Ceccarelli; Mario Venditti; Francesco Pugliese; Carolina Marzuillo; Corrado De Vito; Maria De Giusti; Paolo Villari Journal: Antibiotics (Basel) Date: 2021-03-15