AIMS: To evaluate the association between hemoglobin A(1c) (HbA(1c)), carotid atherosclerosis, arterial stiffness, and peripheral arterial disease (PAD) in Korean type 2 diabetic patients. METHODS: A total of 370 type 2 diabetic patients registered with the public health center in Gokseng-gun, Korea, participated in this study. Following an overnight fast, venous blood was collected and analyzed by high-performance liquid chromatography. The carotid intima-media thickness (IMT), amount of carotid plaque, brachial ankle pulse wave velocity (baPWV), and ankle-brachial index (ABI) of each patient were also assessed. RESULTS: For categorical variables, we performed logistic regression after adjustment for other CVD risk factors. There was a significant association between HbA(1c) and carotid plaque [OR 2.66, 95% confidence interval (CI) 1.01 to 5.67 for the highest vs. the lowest tertile of HbA(1c)], and PAD (OR 3.75, 95% CI 1.30 to 10.81). For continuous variables, we performed analysis of covariance (ANCOVA) after adjustment for other covariates. The mean values of common carotid artery intima-media thickness (CCA-IMT) and baPWV were not significantly different according to the HbA(1c) tertiles. CONCLUSION: HbA(1c) was significantly associated with carotid plaque and PAD, but not CCA-IMT and baPWV in Korean type 2 diabetic patients.
AIMS: To evaluate the association between hemoglobin A(1c) (HbA(1c)), carotid atherosclerosis, arterial stiffness, and peripheral arterial disease (PAD) in Korean type 2 diabeticpatients. METHODS: A total of 370 type 2 diabeticpatients registered with the public health center in Gokseng-gun, Korea, participated in this study. Following an overnight fast, venous blood was collected and analyzed by high-performance liquid chromatography. The carotid intima-media thickness (IMT), amount of carotid plaque, brachial ankle pulse wave velocity (baPWV), and ankle-brachial index (ABI) of each patient were also assessed. RESULTS: For categorical variables, we performed logistic regression after adjustment for other CVD risk factors. There was a significant association between HbA(1c) and carotid plaque [OR 2.66, 95% confidence interval (CI) 1.01 to 5.67 for the highest vs. the lowest tertile of HbA(1c)], and PAD (OR 3.75, 95% CI 1.30 to 10.81). For continuous variables, we performed analysis of covariance (ANCOVA) after adjustment for other covariates. The mean values of common carotid artery intima-media thickness (CCA-IMT) and baPWV were not significantly different according to the HbA(1c) tertiles. CONCLUSION: HbA(1c) was significantly associated with carotid plaque and PAD, but not CCA-IMT and baPWV in Korean type 2 diabeticpatients.
Authors: Manuel A Gomez-Marcos; Leticia Gomez-Sanchez; Maria C Patino-Alonso; Jose I Recio-Rodriguez; Natividad Garcia Regalado; Rafel Ramos; Ruth Marti; Cristina Agudo-Conde; Emiliano Rodriguez-Sanchez; Jose A Maderuelo-Fernandez; Luis Garcia-Ortiz Journal: BMC Cardiovasc Disord Date: 2016-10-28 Impact factor: 2.298
Authors: Seung Won Lee; Hyeon Chang Kim; Yong-Ho Lee; Bo Mi Song; Hansol Choi; Ji Hye Park; Yumie Rhee; Chang Oh Kim Journal: PLoS One Date: 2017-02-08 Impact factor: 3.240