Literature DB >> 20106546

Gene regulation and the origins of human biological uniqueness.

Samuel J Sholtis1, James P Noonan.   

Abstract

What makes us human? It is likely that changes in gene expression and regulation, in addition to those in protein-coding genes, drove the evolution of uniquely human biological traits. In this review, we discuss how efforts to annotate regulatory functions in the human genome are being combined with maps of human-specific sequence acceleration to identify cis-regulatory elements with human-specific activity. Although the evolutionary interpretation of these events is a subject of considerable debate, the technical and analytical means are now at hand to identify the set of evolutionary genetic events that shaped our species. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20106546     DOI： 10.1016/j.tig.2009.12.009

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  10 in total

1.  The emerging roles of eRNAs in transcriptional regulatory networks.

Authors:  Kambiz Mousavi; Hossein Zare; Miroslav Koulnis; Vittorio Sartorelli
Journal:  RNA Biol       Date:  2014-02-07       Impact factor: 4.652

Review 2.  Comparative studies of gene expression and the evolution of gene regulation.

Authors:  Irene Gallego Romero; Ilya Ruvinsky; Yoav Gilad
Journal:  Nat Rev Genet       Date:  2012-06-18       Impact factor: 53.242

Review 3.  Human brain evolution: transcripts, metabolites and their regulators.

Authors:  Mehmet Somel; Xiling Liu; Philipp Khaitovich
Journal:  Nat Rev Neurosci       Date:  2013-01-17       Impact factor: 34.870

4.  Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection.

Authors:  Yoichiro Shibata; Nathan C Sheffield; Olivier Fedrigo; Courtney C Babbitt; Matthew Wortham; Alok K Tewari; Darin London; Lingyun Song; Bum-Kyu Lee; Vishwanath R Iyer; Stephen C J Parker; Elliott H Margulies; Gregory A Wray; Terrence S Furey; Gregory E Crawford
Journal:  PLoS Genet       Date:  2012-06-28       Impact factor: 5.917

5.  The emergence of human-evolutionary medical genomics.

Authors:  Bernard J Crespi
Journal:  Evol Appl       Date:  2010-10-12       Impact factor: 5.183

6.  Evidence of a Conserved Molecular Response to Selection for Increased Brain Size in Primates.

Authors:  Amy M Boddy; Peter W Harrison; Stephen H Montgomery; Jason A Caravas; Mary Ann Raghanti; Kimberley A Phillips; Nicholas I Mundy; Derek E Wildman
Journal:  Genome Biol Evol       Date:  2017-03-01       Impact factor: 3.416

7.  Genome-wide enhancer annotations differ significantly in genomic distribution, evolution, and function.

Authors:  Mary Lauren Benton; Sai Charan Talipineni; Dennis Kostka; John A Capra
Journal:  BMC Genomics       Date:  2019-06-20       Impact factor: 3.969

8.  Signatures of Recent Positive Selection in Enhancers Across 41 Human Tissues.

Authors:  Jiyun M Moon; John A Capra; Patrick Abbot; Antonis Rokas
Journal:  G3 (Bethesda)       Date:  2019-08-08       Impact factor: 3.154

9.  Integrating diverse datasets improves developmental enhancer prediction.

Authors:  Genevieve D Erwin; Nir Oksenberg; Rebecca M Truty; Dennis Kostka; Karl K Murphy; Nadav Ahituv; Katherine S Pollard; John A Capra
Journal:  PLoS Comput Biol       Date:  2014-06-26       Impact factor: 4.475

10.  Divergent connectomic organization delineates genetic evolutionary traits in the human brain.

Authors:  Elisenda Bueichekú; Jose M Gonzalez-de-Echavarri; Laura Ortiz-Teran; Victor Montal; Federico d'Oleire Uquillas; Lola De Marcos; William Orwig; Chan-Mi Kim; Elena Ortiz-Teran; Silvia Basaia; Ibai Diez; Jorge Sepulcre
Journal:  Sci Rep       Date:  2021-10-04       Impact factor: 4.379
  10 in total

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