| Literature DB >> 20105426 |
Shu E Soh1, Dave Qi Rong Ong, Irvin Gerez, Xiaoe Zhang, Pavithra Chollate, Lynette Pei-Chi Shek, Bee Wah Lee, Marion Aw.
Abstract
Probiotics have been shown to enhance specific immune responses to vaccines. We aim to assess the effect of probiotic supplementation on specific IgG antibody responses to Hepatitis B (HepB) vaccination in infants. Compared to controls, probiotic supplementation improved HepB surface antibody responses in subjects receiving monovalent doses of HepB vaccine at 0, 1 month and a DTPa-HepB combination vaccine at 6 months [placebo (n=28): 187.97 (180.70-195.24), probiotic (n=29): 345.70 (339.41-351.99)mIU/ml] (p=0.069), but not those who received 3 monovalent doses [placebo (n=68): 302.34 (296.31-308.37), probiotic (n=77): 302.06 (296.31-307.81)mIU/ml] (p=0.996). Probiotics may enhance specific antibody responses in infants receiving certain Hepatitis B vaccine schedules. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID: 20105426 DOI: 10.1016/j.vaccine.2010.01.020
Source DB: PubMed Journal: Vaccine ISSN: 0264-410X Impact factor: 3.641