Literature DB >> 20104248

Deregulation of H3K27 methylation in cancer.

Eva Martinez-Garcia, Jonathan D Licht.   

Abstract

A new study now reports recurrent somatic mutation of EZH2, a histone methyltransferase that modifies H3K27, in diffuse large B-cell lymphoma (DLBCL). There is now evidence for both increased and decreased activity of enzymes controlling H3K27 methylation in cancer, suggesting that a precise balance of this methylation is critical for normal cell growth.

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Year:  2010        PMID： 20104248     DOI： 10.1038/ng0210-100

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  15 in total

1.  A bivalent chromatin structure marks key developmental genes in embryonic stem cells.

Authors:  Bradley E Bernstein; Tarjei S Mikkelsen; Xiaohui Xie; Michael Kamal; Dana J Huebert; James Cuff; Ben Fry; Alex Meissner; Marius Wernig; Kathrin Plath; Rudolf Jaenisch; Alexandre Wagschal; Robert Feil; Stuart L Schreiber; Eric S Lander
Journal:  Cell       Date:  2006-04-21       Impact factor: 41.582

Review 2.  Chromatin modifications and their function.

Authors:  Tony Kouzarides
Journal:  Cell       Date:  2007-02-23       Impact factor: 41.582

3.  High-resolution profiling of histone methylations in the human genome.

Authors:  Artem Barski; Suresh Cuddapah; Kairong Cui; Tae-Young Roh; Dustin E Schones; Zhibin Wang; Gang Wei; Iouri Chepelev; Keji Zhao
Journal:  Cell       Date:  2007-05-18       Impact factor: 41.582

4.  A histone H3 lysine 27 demethylase regulates animal posterior development.

Authors:  Fei Lan; Peter E Bayliss; John L Rinn; Johnathan R Whetstine; Jordon K Wang; Shuzhen Chen; Shigeki Iwase; Roman Alpatov; Irina Issaeva; Eli Canaani; Thomas M Roberts; Howard Y Chang; Yang Shi
Journal:  Nature       Date:  2007-09-12       Impact factor: 49.962

5.  A model for transmission of the H3K27me3 epigenetic mark.

Authors:  Klaus H Hansen; Adrian P Bracken; Diego Pasini; Nikolaj Dietrich; Simmi S Gehani; Astrid Monrad; Juri Rappsilber; Mads Lerdrup; Kristian Helin
Journal:  Nat Cell Biol       Date:  2008-10-19       Impact factor: 28.824

6.  A polycomb repression signature in metastatic prostate cancer predicts cancer outcome.

Authors:  Jindan Yu; Jianjun Yu; Daniel R Rhodes; Scott A Tomlins; Xuhong Cao; Guoan Chen; Rohit Mehra; Xiaoju Wang; Debashis Ghosh; Rajal B Shah; Sooryanarayana Varambally; Kenneth J Pienta; Arul M Chinnaiyan
Journal:  Cancer Res       Date:  2007-11-15       Impact factor: 12.701

7.  MYC stimulates EZH2 expression by repression of its negative regulator miR-26a.

Authors:  Sandrine Sander; Lars Bullinger; Kay Klapproth; Katja Fiedler; Hans A Kestler; Thomas F E Barth; Peter Möller; Stephan Stilgenbauer; Jonathan R Pollack; Thomas Wirth
Journal:  Blood       Date:  2008-08-19       Impact factor: 22.113

8.  Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

Authors:  Ryan D Morin; Nathalie A Johnson; Tesa M Severson; Andrew J Mungall; Jianghong An; Rodrigo Goya; Jessica E Paul; Merrill Boyle; Bruce W Woolcock; Florian Kuchenbauer; Damian Yap; R Keith Humphries; Obi L Griffith; Sohrab Shah; Henry Zhu; Michelle Kimbara; Pavel Shashkin; Jean F Charlot; Marianna Tcherpakov; Richard Corbett; Angela Tam; Richard Varhol; Duane Smailus; Michelle Moksa; Yongjun Zhao; Allen Delaney; Hong Qian; Inanc Birol; Jacqueline Schein; Richard Moore; Robert Holt; Doug E Horsman; Joseph M Connors; Steven Jones; Samuel Aparicio; Martin Hirst; Randy D Gascoyne; Marco A Marra
Journal:  Nat Genet       Date:  2010-01-17       Impact factor: 38.330

9.  BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.

Authors:  Julian Puppe; Rinske Drost; Xiaoling Liu; Simon A Joosse; Bastiaan Evers; Paulien Cornelissen-Steijger; Petra Nederlof; Qiang Yu; Jos Jonkers; Maarten van Lohuizen; Alexandra M Pietersen
Journal:  Breast Cancer Res       Date:  2009-08-26       Impact factor: 6.466

10.  Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

Authors:  Gijs van Haaften; Gillian L Dalgliesh; Helen Davies; Lina Chen; Graham Bignell; Chris Greenman; Sarah Edkins; Claire Hardy; Sarah O'Meara; Jon Teague; Adam Butler; Jonathan Hinton; Calli Latimer; Jenny Andrews; Syd Barthorpe; Dave Beare; Gemma Buck; Peter J Campbell; Jennifer Cole; Simon Forbes; Mingming Jia; David Jones; Chai Yin Kok; Catherine Leroy; Meng-Lay Lin; David J McBride; Mark Maddison; Simon Maquire; Kirsten McLay; Andrew Menzies; Tatiana Mironenko; Lee Mulderrig; Laura Mudie; Erin Pleasance; Rebecca Shepherd; Raffaella Smith; Lucy Stebbings; Philip Stephens; Gurpreet Tang; Patrick S Tarpey; Rachel Turner; Kelly Turrell; Jennifer Varian; Sofie West; Sara Widaa; Paul Wray; V Peter Collins; Koichi Ichimura; Simon Law; John Wong; Siu Tsan Yuen; Suet Yi Leung; Giovanni Tonon; Ronald A DePinho; Yu-Tzu Tai; Kenneth C Anderson; Richard J Kahnoski; Aaron Massie; Sok Kean Khoo; Bin Tean Teh; Michael R Stratton; P Andrew Futreal
Journal:  Nat Genet       Date:  2009-03-29       Impact factor: 38.330
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  42 in total

1.  Polycomb repressive complex 2 impedes intestinal cell terminal differentiation.

Authors:  Yannick D Benoit; Manon B Lepage; Taoufik Khalfaoui; Eric Tremblay; Nuria Basora; Julie C Carrier; Lorraine J Gudas; Jean-François Beaulieu
Journal:  J Cell Sci       Date:  2012-03-30       Impact factor: 5.285

2.  Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.

Authors:  Christopher J Sneeringer; Margaret Porter Scott; Kevin W Kuntz; Sarah K Knutson; Roy M Pollock; Victoria M Richon; Robert A Copeland
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-15       Impact factor: 11.205

Review 3.  Cancer epigenetics: above and beyond.

Authors:  Mariana Brait; David Sidransky
Journal:  Toxicol Mech Methods       Date:  2011-05       Impact factor: 2.987

4.  The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.

Authors:  Eva Martinez-Garcia; Relja Popovic; Dong-Joon Min; Steve M M Sweet; Paul M Thomas; Leonid Zamdborg; Aaron Heffner; Christine Will; Laurence Lamy; Louis M Staudt; David L Levens; Neil L Kelleher; Jonathan D Licht
Journal:  Blood       Date:  2010-10-25       Impact factor: 22.113

5.  Quantitative proteomics reveals histone modifications in crosstalk with H3 lysine 27 methylation.

Authors:  Chunchao Zhang; Shan Gao; Anthony J Molascon; Yifan Liu; Philip C Andrews
Journal:  Mol Cell Proteomics       Date:  2014-01-01       Impact factor: 5.911

6.  Identification of somatic mutations in parathyroid tumors using whole-exome sequencing.

Authors:  M Kyle Cromer; Lee F Starker; Murim Choi; Robert Udelsman; Carol Nelson-Williams; Richard P Lifton; Tobias Carling
Journal:  J Clin Endocrinol Metab       Date:  2012-06-27       Impact factor: 5.958

Review 7.  Epigenetic regulation in RCC: opportunities for therapeutic intervention?

Authors:  James Larkin; Xin Yi Goh; Marcus Vetter; Lisa Pickering; Charles Swanton
Journal:  Nat Rev Urol       Date:  2012-01-17       Impact factor: 14.432

8.  Polycomb repressive complex 2 is required for MLL-AF9 leukemia.

Authors:  Tobias Neff; Amit U Sinha; Michael J Kluk; Nan Zhu; Mohamed H Khattab; Lauren Stein; Huafeng Xie; Stuart H Orkin; Scott A Armstrong
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-06       Impact factor: 11.205

9.  Fine-tuning AKT kinase activity through direct lysine methylation.

Authors:  Jianping Guo; Wenyi Wei
Journal:  Cell Cycle       Date:  2019-05-03       Impact factor: 4.534

Review 10.  Prognosis of Primary Myelofibrosis in the Genomic Era.

Authors:  Prithviraj Bose; Srdan Verstovsek
Journal:  Clin Lymphoma Myeloma Leuk       Date:  2016-08
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