OBJECTIVE: Living with a demented person has been associated with high levels of clinical depression and anxiety. However, there are no prospective studies that allow good estimates of the incidence of depression and anxiety. In this study, the authors assess the long-term incidence of depression and anxiety in the spouses of patients with dementia as recorded by general practitioners. DESIGN: Prospective naturalistic cohort study with a comparison group. Data from medical records in 2001-2007 were analyzed. PARTICIPANTS: Two hundred eighteen spouses of patients with dementia and 353 age and gender-matched spouses of nondemented persons. SETTING: Seventy-one general practices in the Netherlands with a listed source population of 320,309 patients. MEASUREMENTS: Incidence rates (IRs) per 1,000 person-years and hazard ratios (HRs) of depression and anxiety; prescription rates (per 1,000 person-years) for antidepressants and anxiolytics. RESULTS: A new episode of depression was diagnosed in 18 spouses and 7 comparison spouses (IRs of 18.8/1,000 person-years and 4.4/1,000 person-years, respectively). Spouses of patients with dementia were far more likely to be diagnosed with depression than the comparison spouses (HR, 4.16; 95% CI: 1.73-9.98). Spouses did not have a higher incidence of anxiety than the comparison group (HR, 1.26; 95% CI: 0.58-2.71). The prescription rates for both antidepressants and anxiolytics were significantly higher for spouses than for the comparison group. CONCLUSION: The spouses of patients with dementia have a fourfold higher risk of a diagnosis of depression than the spouses of nondemented persons. The authors could not establish this for anxiety.
OBJECTIVE: Living with a demented person has been associated with high levels of clinical depression and anxiety. However, there are no prospective studies that allow good estimates of the incidence of depression and anxiety. In this study, the authors assess the long-term incidence of depression and anxiety in the spouses of patients with dementia as recorded by general practitioners. DESIGN: Prospective naturalistic cohort study with a comparison group. Data from medical records in 2001-2007 were analyzed. PARTICIPANTS: Two hundred eighteen spouses of patients with dementia and 353 age and gender-matched spouses of nondemented persons. SETTING: Seventy-one general practices in the Netherlands with a listed source population of 320,309 patients. MEASUREMENTS: Incidence rates (IRs) per 1,000 person-years and hazard ratios (HRs) of depression and anxiety; prescription rates (per 1,000 person-years) for antidepressants and anxiolytics. RESULTS: A new episode of depression was diagnosed in 18 spouses and 7 comparison spouses (IRs of 18.8/1,000 person-years and 4.4/1,000 person-years, respectively). Spouses of patients with dementia were far more likely to be diagnosed with depression than the comparison spouses (HR, 4.16; 95% CI: 1.73-9.98). Spouses did not have a higher incidence of anxiety than the comparison group (HR, 1.26; 95% CI: 0.58-2.71). The prescription rates for both antidepressants and anxiolytics were significantly higher for spouses than for the comparison group. CONCLUSION: The spouses of patients with dementia have a fourfold higher risk of a diagnosis of depression than the spouses of nondemented persons. The authors could not establish this for anxiety.
Authors: Isabel Mosquera; Itziar Vergara; Isabel Larrañaga; Mónica Machón; María del Río; Carlos Calderón Journal: Qual Life Res Date: 2015-10-16 Impact factor: 4.147
Authors: Jenna L Wells; Casey L Brown; Alice Y Hua; Peter D Soyster; Kuan-Hua Chen; Deepika R Dokuru; Giovanni Coppola; Claudia M Haase; Robert W Levenson Journal: Am J Geriatr Psychiatry Date: 2019-04-29 Impact factor: 4.105
Authors: Karlijn J Joling; Filip Smit; Harm W J van Marwijk; Henriëtte E van der Horst; Philip Scheltens; Richard Schulz; Hein P J van Hout Journal: Int Psychogeriatr Date: 2011-09-01 Impact factor: 3.878
Authors: J E Lutomski; N J A van Exel; G I J M Kempen; E P Moll van Charante; W P J den Elzen; A P D Jansen; P F M Krabbe; B Steunenberg; E W Steyerberg; M G M Olde Rikkert; R J F Melis Journal: Qual Life Res Date: 2014-11-08 Impact factor: 4.147
Authors: Jhon Alexander Moreno; Elizabeth Nicholls; Natalia Ojeda; Carlos José De los Reyes-Aragón; Diego Rivera; Juan Carlos Arango-Lasprilla Journal: J Cross Cult Gerontol Date: 2015-12