BACKGROUND: Auditory P50 sensory gating deficits correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The well-supported role of catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) genes in neurodevelopment and cognition make a strong theoretical case for their influence on the P50 endophenotype. METHOD: The possible role of NRG1, COMT Val158Met and BDNF Val66Met gene polymorphisms on the P50 endophenotype was examined in a large sample consisting of psychotic patients, their unaffected relatives and unrelated healthy controls using linear regression analyses. RESULTS: Although P50 deficits were present in patients and their unaffected relatives, there was no evidence for an association between NRG1, COMT Val158Met or BDNF Val66Met genotypes and the P50 endophenotype. CONCLUSIONS: The evidence from our large study suggests that any such association between P50 indices and NRG1, COMT Val158Met or BDNF Val66Met genotypes, if present, must be very subtle.
BACKGROUND: Auditory P50 sensory gating deficits correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The well-supported role of catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) genes in neurodevelopment and cognition make a strong theoretical case for their influence on the P50 endophenotype. METHOD: The possible role of NRG1, COMT Val158Met and BDNF Val66Met gene polymorphisms on the P50 endophenotype was examined in a large sample consisting of psychoticpatients, their unaffected relatives and unrelated healthy controls using linear regression analyses. RESULTS: Although P50 deficits were present in patients and their unaffected relatives, there was no evidence for an association between NRG1, COMT Val158Met or BDNF Val66Met genotypes and the P50 endophenotype. CONCLUSIONS: The evidence from our large study suggests that any such association between P50 indices and NRG1, COMT Val158Met or BDNF Val66Met genotypes, if present, must be very subtle.
Authors: Mohammadreza Mokhtari; Balaji Narayanan; Jordan P Hamm; Pauline Soh; Vince D Calhoun; Gualberto Ruaño; Mohan Kocherla; Andreas Windemuth; Brett A Clementz; Carol A Tamminga; John A Sweeney; Matcheri S Keshavan; Godfrey D Pearlson Journal: Schizophr Bull Date: 2015-10-12 Impact factor: 9.306
Authors: Boris B Quednow; Jürgen Brinkmeyer; Arian Mobascher; Michael Nothnagel; Francesco Musso; Gerhard Gründer; Noah Savary; Nadine Petrovsky; Ingo Frommann; Leonhard Lennertz; Katja N Spreckelmeyer; Thomas F Wienker; Norbert Dahmen; Norbert Thuerauf; Marion Clepce; Falk Kiefer; Tomislav Majic; Rainald Mössner; Wolfgang Maier; Jürgen Gallinat; Amalia Diaz-Lacava; Mohammad R Toliat; Holger Thiele; Peter Nürnberg; Michael Wagner; Georg Winterer Journal: Proc Natl Acad Sci U S A Date: 2012-03-26 Impact factor: 11.205
Authors: S de la Salle; D Smith; J Choueiry; D Impey; T Philippe; H Dort; A Millar; P Albert; V Knott Journal: Neuroscience Date: 2013-03-25 Impact factor: 3.590
Authors: Madiha Shaikh; Mei-Hua Hall; Katja Schulze; Anirban Dutt; Kuang Li; Ian Williams; Muriel Walshe; Miguel Constante; Matthew Broome; Marco Picchioni; Timothea Toulopoulou; David Collier; Daniel Stahl; Fruhling Rijsdijk; John Powell; Robin M Murray; Maria Arranz; Elvira Bramon Journal: Schizophr Bull Date: 2011-08-30 Impact factor: 9.306