Literature DB >> 20102311

Dendritic cell function in lupus: Independent contributors or victims of aberrant immune regulation.

Katalin Kis-Toth1, George C Tsokos.   

Abstract

Dendritic cells (DCs) represent an important component of the immune system connecting the innate and adaptive immune responses. They are able to trigger strong immunity as well as tolerance against certain antigens, and therefore it is obvious that they have a central role in the expression of immunological diseases. However, because DCs are sparse, heterogeneous and plastic, their exact role in complex autoimmune diseases, such as systemic lupus erythematosus (SLE) remains not well defined. In this review, we make an attempt to summarize critically recent knowledge on the role of conventional DCs in the expression of autoimmunity and pathology in SLE.

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Year:  2010        PMID： 20102311     DOI： 10.3109/08916930903214041

Source DB:  PubMed          Journal:  Autoimmunity        ISSN： 0891-6934            Impact factor:   2.815


  12 in total

1.  Gene expression profiles identify both MyD88-independent and MyD88-dependent pathways involved in the maturation of dendritic cells mediated by heparan sulfate: a novel adjuvant.

Authors:  Meini Wu; Haixuan Wang; Jiandong Shi; Jing Sun; Zhiqing Duan; Yanhan Li; Jianfang Li; Ningzhu Hu; Yiju Wei; Yang Chen; Yunzhang Hu
Journal:  Hum Vaccin Immunother       Date:  2014       Impact factor: 3.452

Review 2.  The Role of Damage-Associated Molecular Patterns in Human Diseases: Part I - Promoting inflammation and immunity.

Authors:  Walter G Land
Journal:  Sultan Qaboos Univ Med J       Date:  2015-01-21

Review 3.  The dysregulation of cytokine networks in systemic lupus erythematosus.

Authors:  Sokratis A Apostolidis; Linda A Lieberman; Katalin Kis-Toth; José C Crispín; George C Tsokos
Journal:  J Interferon Cytokine Res       Date:  2011-08-30       Impact factor: 2.607

4.  Estrogen receptor alpha modulates Toll-like receptor signaling in murine lupus.

Authors:  Melissa A Cunningham; Osama S Naga; Jackie G Eudaly; Jennifer L Scott; Gary S Gilkeson
Journal:  Clin Immunol       Date:  2012-04-20       Impact factor: 3.969

5.  Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation.

Authors:  Carla M Cuda; Alexander V Misharin; Angelica K Gierut; Rana Saber; G Kenneth Haines; Jack Hutcheson; Stephen M Hedrick; Chandra Mohan; G Scott Budinger; Christian Stehlik; Harris Perlman
Journal:  J Immunol       Date:  2014-05-07       Impact factor: 5.422

6.  Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells.

Authors:  Shaukat Ali Khan; Johannes Nowatzky; Sonia Jiménez-Branda; Jeffrey David Greenberg; Robert Clancy; Jill Buyon; Nina Bhardwaj
Journal:  Exp Mol Pathol       Date:  2013-06-14       Impact factor: 3.362

Review 7.  Metabolic regulation of organelle homeostasis in lupus T cells.

Authors:  Tiffany N Caza; Gergely Talaber; Andras Perl
Journal:  Clin Immunol       Date:  2012-07-13       Impact factor: 3.969

8.  Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.

Authors:  Chrystelle Lamagna; Patrizia Scapini; Jessica A van Ziffle; Anthony L DeFranco; Clifford A Lowell
Journal:  Proc Natl Acad Sci U S A       Date:  2013-08-12       Impact factor: 11.205

9.  The nanomaterial-dependent modulation of dendritic cells and its potential influence on therapeutic immunosuppression in lupus.

Authors:  Michael Look; W Mark Saltzman; Joe Craft; Tarek M Fahmy
Journal:  Biomaterials       Date:  2013-11-01       Impact factor: 12.479

Review 10.  The real culprit in systemic lupus erythematosus: abnormal epigenetic regulation.

Authors:  Haijing Wu; Ming Zhao; Christopher Chang; Qianjin Lu
Journal:  Int J Mol Sci       Date:  2015-05-15       Impact factor: 5.923
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