Simone Sep1, Luc Smits, Martin Prins, Louis Peeters. 1. Department of Obstetrics and Gynecology, University Medical Centre Maastricht, Maastricht, The Netherlands. simone.sep@og.unimaas.nl
Abstract
OBJECTIVE: To summarize reported evidence on the performance and clinical usefulness of prediction tests for recurrent hypertensive disease in pregnancy. METHODS: A literature search was conducted in MEDLINE/PubMed and EMBASE. Test characteristics were extracted for relevant reports. RESULTS: Thirty-three of 4,311 articles found met the inclusion criteria. Twenty-four potential predictors were identified. Pre-pregnant plasma volume, uterine-artery blood flow velocity profiles, and combined longitudinal patterns of in-pregnancy laboratory variables had reasonable predictive capacity, but also some practical shortcomings. Confidence intervals were often wide. CONCLUSIONS: Although evidence points to promising predictive accuracy of some tests, immediate applicability is hampered by statistical imprecision and clinical drawbacks.
OBJECTIVE: To summarize reported evidence on the performance and clinical usefulness of prediction tests for recurrent hypertensive disease in pregnancy. METHODS: A literature search was conducted in MEDLINE/PubMed and EMBASE. Test characteristics were extracted for relevant reports. RESULTS: Thirty-three of 4,311 articles found met the inclusion criteria. Twenty-four potential predictors were identified. Pre-pregnant plasma volume, uterine-artery blood flow velocity profiles, and combined longitudinal patterns of in-pregnancy laboratory variables had reasonable predictive capacity, but also some practical shortcomings. Confidence intervals were often wide. CONCLUSIONS: Although evidence points to promising predictive accuracy of some tests, immediate applicability is hampered by statistical imprecision and clinical drawbacks.
Authors: Denise H J Delahaije; Sander M J van Kuijk; Carmen D Dirksen; Simone J S Sep; Louis L Peeters; Marc E Spaanderman; Hein W Bruinse; Laura D de Wit-Zuurendonk; Joris A M van der Post; Johannes J Duvekot; Jim van Eyck; Mariëlle G van Pampus; Mark A B H M van der Hoeven; Luc J Smits Journal: BMC Pregnancy Childbirth Date: 2010-10-11 Impact factor: 3.007