J H Check1, J Amui, J K Choe, D Brasile. 1. The University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA. laurie@ccivf.com
Abstract
PURPOSE: To determine if either too little or too much of a rise in serum progesterone (P) on the day after human chorionic gonadotropin (hCG) injection has any negative impact on pregnancy outcome following in vitro fertilization-embryo transfer (IVF-ET). METHODS: Retrospective review. Three progesterone groups established--low, normal and high. RESULTS: There was a significantly higher clinical pregnancy rate in the normal P group vs low or high. There were no significant differences in ongoing delivered pregnancy rates but a trend for higher implantation rates in the normal P group. CONCLUSIONS: These data are consistent with the hypothesis that either too little or too much P can adversely effect implantation. However, the differences are not of sufficient magnitude to warrant a clinical intervention, e.g., deferring fresh transfer and freezing the embryos for future transfer.
PURPOSE: To determine if either too little or too much of a rise in serum progesterone (P) on the day after human chorionic gonadotropin (hCG) injection has any negative impact on pregnancy outcome following in vitro fertilization-embryo transfer (IVF-ET). METHODS: Retrospective review. Three progesterone groups established--low, normal and high. RESULTS: There was a significantly higher clinical pregnancy rate in the normal P group vs low or high. There were no significant differences in ongoing delivered pregnancy rates but a trend for higher implantation rates in the normal P group. CONCLUSIONS: These data are consistent with the hypothesis that either too little or too much P can adversely effect implantation. However, the differences are not of sufficient magnitude to warrant a clinical intervention, e.g., deferring fresh transfer and freezing the embryos for future transfer.
Authors: N P Polyzos; E Anckaert; P Drakopoulos; H Tournaye; J Schiettecatte; H Donner; G Bobba; G Miles; W D J Verhagen-Kamerbeek; E Bosch Journal: J Endocrinol Invest Date: 2020-03-13 Impact factor: 4.256