BACKGROUND: This study evaluated the outcome of patients treated for rectal cancer and synchronous hepatic metastases in the era of effective induction radiotherapy and chemotherapy. METHODS: All patients undergoing surgical treatment of rectal cancer and synchronous liver metastases between 2000 and 2007 were identified retrospectively from a prospectively collected database. Three approaches were followed: the classical staged, the simultaneous and the liver-first approach. RESULTS: Of 57 patients identified, the primary tumour was resected first in 29 patients (group 1), simultaneous resection was performed in eight patients (group 2), and 20 patients underwent a liver-first approach (group 3). The overall morbidity rate was 24.6 per cent; there was no in-hospital mortality. Median in-hospital stay was significantly shorter for the simultaneous approach (9 days versus 18 and 15 days for groups 1 and 3 respectively; P < 0.001). The overall 5-year survival rate was 38 per cent, with an estimated median survival of 47 months. CONCLUSION: Long-term survival can be achieved using an individualized approach, with curative intent, in patients with rectal cancer and synchronous liver metastases. Simultaneous resections as well as the liver-first approach are attractive alternatives to traditional staged resections. (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
BACKGROUND: This study evaluated the outcome of patients treated for rectal cancer and synchronous hepatic metastases in the era of effective induction radiotherapy and chemotherapy. METHODS: All patients undergoing surgical treatment of rectal cancer and synchronous liver metastases between 2000 and 2007 were identified retrospectively from a prospectively collected database. Three approaches were followed: the classical staged, the simultaneous and the liver-first approach. RESULTS: Of 57 patients identified, the primary tumour was resected first in 29 patients (group 1), simultaneous resection was performed in eight patients (group 2), and 20 patients underwent a liver-first approach (group 3). The overall morbidity rate was 24.6 per cent; there was no in-hospital mortality. Median in-hospital stay was significantly shorter for the simultaneous approach (9 days versus 18 and 15 days for groups 1 and 3 respectively; P < 0.001). The overall 5-year survival rate was 38 per cent, with an estimated median survival of 47 months. CONCLUSION: Long-term survival can be achieved using an individualized approach, with curative intent, in patients with rectal cancer and synchronous liver metastases. Simultaneous resections as well as the liver-first approach are attractive alternatives to traditional staged resections. (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Authors: H Salvador-Rosés; S López-Ben; P Planellas; E Canals; M Casellas-Robert; R Farrés; E Ramos; A Codina-Cazador; J Figueras Journal: Clin Transl Oncol Date: 2017-07-13 Impact factor: 3.405
Authors: Ryan Anthony F Agas; Lester Bryan A Co; J C Kennetth M Jacinto; Kelvin Ken L Yu; Paolo G Sogono; Warren R Bacorro; Teresa T Sy Ortin Journal: J Gastrointest Cancer Date: 2018-12
Authors: H Salvador-Rosés; S López-Ben; M Casellas-Robert; P Planellas; N Gómez-Romeu; R Farrés; E Ramos; A Codina-Cazador; J Figueras Journal: Clin Transl Oncol Date: 2017-12-22 Impact factor: 3.405
Authors: Mechteld C de Jong; Ronald M van Dam; Monique Maas; Marc H A Bemelmans; Steven W M Olde Damink; Geerard L Beets; Cornelis H C Dejong Journal: HPB (Oxford) Date: 2011-09-05 Impact factor: 3.647