OBJECTIVE: In this study, a biological extracellular matrix was compared with a moist wound dressing to determine its effectiveness in the treatment of mixed arterial/venous and venous ulcers. METHODS: Patients were evaluated for complete wound healing, time to dressing change, and formation of granulation tissue. RESULTS: Extracellular matrix-treated ulcers achieved complete healing on average in 5.4 weeks as compared with 8.3 weeks for the control group treated with moist wound dressing (P = .02). At the primary time point evaluated (8 weeks), complete wound closure was achieved in 80% of extracellular matrix-treated ulcers compared with 65% of ulcers in the control group (P < .05). Statistically significant differences favoring the extracellular-matrix treatment group were also reported for time to dressing change (P < .05), and for percentage of granulation tissue formed (P < .05). CONCLUSION: Overall, the biological extracellular matrix was more beneficial than moist wound dressings for the treatment of patients with mixed arterial/venous or venous ulcers.
RCT Entities:
OBJECTIVE: In this study, a biological extracellular matrix was compared with a moist wound dressing to determine its effectiveness in the treatment of mixed arterial/venous and venous ulcers. METHODS:Patients were evaluated for complete wound healing, time to dressing change, and formation of granulation tissue. RESULTS: Extracellular matrix-treated ulcers achieved complete healing on average in 5.4 weeks as compared with 8.3 weeks for the control group treated with moist wound dressing (P = .02). At the primary time point evaluated (8 weeks), complete wound closure was achieved in 80% of extracellular matrix-treated ulcers compared with 65% of ulcers in the control group (P < .05). Statistically significant differences favoring the extracellular-matrix treatment group were also reported for time to dressing change (P < .05), and for percentage of granulation tissue formed (P < .05). CONCLUSION: Overall, the biological extracellular matrix was more beneficial than moist wound dressings for the treatment of patients with mixed arterial/venous or venous ulcers.
Authors: Michael S Hu; Zeshaan N Maan; Jen-Chieh Wu; Robert C Rennert; Wan Xing Hong; Tiffany S Lai; Alexander T M Cheung; Graham G Walmsley; Michael T Chung; Adrian McArdle; Michael T Longaker; H Peter Lorenz Journal: Ann Biomed Eng Date: 2014-05-01 Impact factor: 3.934
Authors: Kritika Iyer; Zhuo Chen; Teja Ganapa; Benjamin M Wu; Bill Tawil; Chase S Linsley Journal: Tissue Eng Regen Med Date: 2018-08-14 Impact factor: 4.169
Authors: Shawn M Cazzell; Darrell L Lange; Jaime E Dickerson; Herbert B Slade Journal: Adv Wound Care (New Rochelle) Date: 2015-12-01 Impact factor: 4.730