| Literature DB >> 20100627 |
Keren Mizrachi1, Revital Aricha, Tali Feferman, Neta Kela-Madar, Ilana Mandel, Tamar Paperna, Ariel Miller, Avraham Ben-Nun, Sonia Berrih-Aknin, Miriam C Souroujon, Sara Fuchs.
Abstract
We have previously shown that several phosphodiesterase (PDE) subtypes are up-regulated in muscles and lymph node cells (LNC) of rats with experimental autoimmune myasthenia gravis (EAMG). In the present study we investigated PDE expression during the course of EAMG and experimental allergic encephalomyelitis (EAE) and found that the up-regulated expression of selected PDE subtypes in both experimental models is correlated with disease severity. In EAMG, PDE expression is correlated also with muscle damage. A similar up-regulation of PDE was also observed in the respective human diseases, MG and multiple sclerosis (MS). Our findings suggest that change in PDE expression levels is a general phenomenon in autoimmune diseases and may also be used as a marker for disease severity. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20100627 DOI： 10.1016/j.jneuroim.2009.12.012
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478