BACKGROUND: It is noteworthy that there is a clear clinical, epidemiological and pathophysiological association between upper and lower airway inflammation in rhinitis and asthma. OBJECTIVE: The aim of this study was to compare the eosinophil counts in induced sputum and nasal lavage fluids in asthma, checking their association and the accuracy of nasal eosinophilia as a predictor of sputum eosinophilia by a cross-sectional study. METHODS: The clinical evaluation, asthma control questionnaire (ACQ), pre- and post-bronchodilator spirometry, nasal and sputum sample was performed. The nasal eosinophilia was analysed by a receiver operating curve and logistic regression model. RESULTS: In 140 adults, the post-bronchodilator forced expiratory volume in 1 s (FEV(1)) did not differ between patients with or without sputum eosinophilia (0.18). After adjusted for upper airway symptoms, age, ACQ score and post-bronchodilator FEV(1), sputum eosinophilia was associated with 52 times increase in odds of nasal eosinophilia, whereas each 1% increase in bronchodilator response was associated with 7% increase in odds of nasal eosinophilia. CONCLUSION: This study brings further evidence that upper airway diseases are an important component of the asthma syndrome. Furthermore, monitoring of nasal eosinophilia by quantitative cytology may be useful as a surrogate of sputum cytology in as a component of composite measurement for determining airway inflammation.
BACKGROUND: It is noteworthy that there is a clear clinical, epidemiological and pathophysiological association between upper and lower airway inflammation in rhinitis and asthma. OBJECTIVE: The aim of this study was to compare the eosinophil counts in induced sputum and nasal lavage fluids in asthma, checking their association and the accuracy of nasal eosinophilia as a predictor of sputum eosinophilia by a cross-sectional study. METHODS: The clinical evaluation, asthma control questionnaire (ACQ), pre- and post-bronchodilator spirometry, nasal and sputum sample was performed. The nasal eosinophilia was analysed by a receiver operating curve and logistic regression model. RESULTS: In 140 adults, the post-bronchodilator forced expiratory volume in 1 s (FEV(1)) did not differ between patients with or without sputum eosinophilia (0.18). After adjusted for upper airway symptoms, age, ACQ score and post-bronchodilator FEV(1), sputum eosinophilia was associated with 52 times increase in odds of nasal eosinophilia, whereas each 1% increase in bronchodilator response was associated with 7% increase in odds of nasal eosinophilia. CONCLUSION: This study brings further evidence that upper airway diseases are an important component of the asthma syndrome. Furthermore, monitoring of nasal eosinophilia by quantitative cytology may be useful as a surrogate of sputum cytology in as a component of composite measurement for determining airway inflammation.
Authors: Christopher D Codispoti; David I Bernstein; Linda Levin; Tiina Reponen; Patrick H Ryan; Jocelyn M Biagini Myers; Manuel Villareal; Jeff Burkle; Zana Lummus; James E Lockey; Gurjit K Khurana Hershey; Grace K LeMasters Journal: Ann Allergy Asthma Immunol Date: 2015-03 Impact factor: 6.347
Authors: M A Rank; S I Ochkur; J C Lewis; H G Teaford; L J Wesselius; R A Helmers; N A Lee; P Nair; J J Lee Journal: Allergy Date: 2015-12-24 Impact factor: 13.146
Authors: Hille Suojalehto; Pia Kinaret; Maritta Kilpeläinen; Elina Toskala; Niina Ahonen; Henrik Wolff; Harri Alenius; Anne Puustinen Journal: PLoS One Date: 2015-05-28 Impact factor: 3.240
Authors: Giuseppe Di Cara; Alessia Carelli; Arianna Latini; Elisa Panfili; Ilaria Bizzarri; Giorgio Ciprandi; Serena Buttafava; Franco Frati; Alberto Verrotti Journal: World Allergy Organ J Date: 2015-04-23 Impact factor: 4.084
Authors: Cristina Ardura-Garcia; Erick Arias; Paola Hurtado; Laura J Bonnett; Carlos Sandoval; Augusto Maldonado; Lisa J Workman; Thomas A E Platts-Mills; Philip J Cooper; John D Blakey Journal: Eur Respir J Date: 2019-11-14 Impact factor: 16.671