| Literature DB >> 20099863 |
Elisabeth Christiansen1, Maria E Due-Hansen, Trond Ulven.
Abstract
A protocol for rapid and efficient Pd/Cu-catalyzed coupling of aryl bromides and iodides to terminal alkynes has been developed with use of 2-(di-tert-butylphosphino)-N-phenylindole (cataCXium PIntB) as ligand in TMEDA and water. The new protocol successfully couples substrates which failed with standard Sonogashira conditions, and enables an efficient general synthetic route to free fatty acid 1 (FFA1) receptor ligands from 3-(4-bromophenyl)propionic acid.Entities:
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Year: 2010 PMID： 20099863 DOI： 10.1021/jo902533p
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354