Literature DB >> 2009961

Immunological studies of the toxic site in ammodytoxin A.

V Curin-Serbec1, D Novak, J Babnik, D Turk, F Gubensek.   

Abstract

Two monoclonal antibodies against the native ammodytoxin A and four site-directed polyclonal antibodies against synthetic peptides derived from the primary structure of the toxin were prepared in order to estimate the localization of its toxic site. Some of the antibodies neutralized the lethal toxicity of the toxin, thus indicating an approximate position of the toxic or receptor binding site on the molecule that is different from those predicted by comparison with a number of known sequences.

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Year:  1991        PMID: 2009961     DOI: 10.1016/0014-5793(91)80231-q

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  5 in total

1.  Biological and structural characterization of crotoxin and new isoform of crotoxin B PLA(2) (F6a) from Crotalus durissus collilineatus snake venom.

Authors:  Luis Alberto Ponce-Soto; Bruno Lomonte; Lea Rodrigues-Simioni; José Camillo Novello; Sergio Marangoni
Journal:  Protein J       Date:  2007-06       Impact factor: 2.371

2.  Charge reversal of ammodytoxin A, a phospholipase A2-toxin, does not abolish its neurotoxicity.

Authors:  P Prijatelj; A Copic; I Krizaj; F Gubensek; J Pungercar
Journal:  Biochem J       Date:  2000-12-01       Impact factor: 3.857

3.  An aromatic, but not a basic, residue is involved in the toxicity of group-II phospholipase A2 neurotoxins.

Authors:  J Pungercar; I Krizaj; N S Liang; F Gubensek
Journal:  Biochem J       Date:  1999-07-01       Impact factor: 3.857

4.  Biochemical, pharmacological and structural characterization of two PLA2 isoforms Cdr-12 and Cdr-13 from Crotalus durissus ruruima snake venom.

Authors:  Luis Alberto Ponce-Soto; Paulo Aparecido Baldasso; Frey Francisco Romero-Vargas; Flávia V Winck; José Camillo Novello; Sergio Marangoni
Journal:  Protein J       Date:  2007-01       Impact factor: 4.000

Review 5.  Innovative Immunization Strategies for Antivenom Development.

Authors:  Erick Bermúdez-Méndez; Albert Fuglsang-Madsen; Sofie Føns; Bruno Lomonte; José María Gutiérrez; Andreas Hougaard Laustsen
Journal:  Toxins (Basel)       Date:  2018-11-02       Impact factor: 4.546

  5 in total

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