PURPOSE: To assess the relationships of microstructural damage in the cerebral white matter (WM), as measured by diffusion tensor imaging (DTI), with clinical parameters and magnetic resonance imaging (MRI) measures of focal tissue damage in patients with multiple sclerosis (MS). MATERIALS AND METHODS: Forty-five relapsing-remitting (RR) MS patients (12 male, 33 female; median age = 29 years, Expanded Disability Status Scale (EDSS) = 1.5, disease duration = 3 years) were studied. T2-lesion masks were created and voxelwise DTI analyses performed with Tract-Based Spatial Statistics (TBSS). RESULTS: T2-lesion volume (T2-LV) was significantly (P < 0.05, corrected) correlated with fractional anisotropy (FA) in both lesions and normal-appearing WM (NAWM). Relationships (P = 0.08, corrected) between increasing EDSS score and decreasing FA were found in the splenium of the corpus callosum (sCC) and along the pyramidal tract (PY). All FA associations were driven by changes in the perpendicular (to primary tract direction) diffusivity. No significant global and voxelwise FA changes were found over a 2-year follow-up. CONCLUSION: FA changes related to clinical disability in RR-MS patients with minor clinical disability are localized to specific WM tracts such as the sCC and PY and are driven by changes in perpendicular diffusivity both within lesions and NAWM. Longitudinal DTI measurements do not seem able to chart the early disease course in the WM of MS patients.
PURPOSE: To assess the relationships of microstructural damage in the cerebral white matter (WM), as measured by diffusion tensor imaging (DTI), with clinical parameters and magnetic resonance imaging (MRI) measures of focal tissue damage in patients with multiple sclerosis (MS). MATERIALS AND METHODS: Forty-five relapsing-remitting (RR) MSpatients (12 male, 33 female; median age = 29 years, Expanded Disability Status Scale (EDSS) = 1.5, disease duration = 3 years) were studied. T2-lesion masks were created and voxelwise DTI analyses performed with Tract-Based Spatial Statistics (TBSS). RESULTS: T2-lesion volume (T2-LV) was significantly (P < 0.05, corrected) correlated with fractional anisotropy (FA) in both lesions and normal-appearing WM (NAWM). Relationships (P = 0.08, corrected) between increasing EDSS score and decreasing FA were found in the splenium of the corpus callosum (sCC) and along the pyramidal tract (PY). All FA associations were driven by changes in the perpendicular (to primary tract direction) diffusivity. No significant global and voxelwise FA changes were found over a 2-year follow-up. CONCLUSION:FA changes related to clinical disability in RR-MSpatients with minor clinical disability are localized to specific WM tracts such as the sCC and PY and are driven by changes in perpendicular diffusivity both within lesions and NAWM. Longitudinal DTI measurements do not seem able to chart the early disease course in the WM of MSpatients.
Authors: Waqar Rashid; Andreas Hadjiprocopis; Gerard Davies; Collette Griffin; Declan Chard; Michaela Tiberio; Dan Altmann; Claudia Wheeler-Kingshott; Dan Tozer; Alan Thompson; David H Miller Journal: J Neurol Date: 2008-03-20 Impact factor: 4.849
Authors: Sheng-Kwei Song; Jun Yoshino; Tuan Q Le; Shiow-Jiuan Lin; Shu-Wei Sun; Anne H Cross; Regina C Armstrong Journal: Neuroimage Date: 2005-05-15 Impact factor: 6.556
Authors: Francesca Caramia; Patrizia Pantano; Silvia Di Legge; Maria Cristina Piattella; Delia Lenzi; Andrea Paolillo; Walter Nucciarelli; Gian Luigi Lenzi; Luigi Bozzao; Carlo Pozzilli Journal: Magn Reson Imaging Date: 2002-06 Impact factor: 2.546
Authors: Stephen M Smith; Mark Jenkinson; Heidi Johansen-Berg; Daniel Rueckert; Thomas E Nichols; Clare E Mackay; Kate E Watkins; Olga Ciccarelli; M Zaheer Cader; Paul M Matthews; Timothy E J Behrens Journal: Neuroimage Date: 2006-04-19 Impact factor: 6.556
Authors: Chris H Polman; Stephen C Reingold; Gilles Edan; Massimo Filippi; Hans-Peter Hartung; Ludwig Kappos; Fred D Lublin; Luanne M Metz; Henry F McFarland; Paul W O'Connor; Magnhild Sandberg-Wollheim; Alan J Thompson; Brian G Weinshenker; Jerry S Wolinsky Journal: Ann Neurol Date: 2005-12 Impact factor: 10.422
Authors: O Ciccarelli; C A Wheeler-Kingshott; M A McLean; M Cercignani; K Wimpey; D H Miller; A J Thompson Journal: Brain Date: 2007-08 Impact factor: 13.501
Authors: Kerstin Bendfeldt; Louis Hofstetter; Pascal Kuster; Stefan Traud; Nicole Mueller-Lenke; Yvonne Naegelin; Ludwig Kappos; Achim Gass; Thomas E Nichols; Frederik Barkhof; Hugo Vrenken; Stefan D Roosendaal; Jeroen J G Geurts; Ernst-Wilhelm Radue; Stefan J Borgwardt Journal: Hum Brain Mapp Date: 2011-04-29 Impact factor: 5.038
Authors: Fernanda Tovar-Moll; Iordanis E Evangelou; Annie W Chiu; Sungyoung Auh; Christina Chen; Mary Ehrmantraut; Joan M Ohayon; Nancy Richert; Francesca Bagnato Journal: J Neuroimaging Date: 2014-10-16 Impact factor: 2.486
Authors: D M Harrison; B S Caffo; N Shiee; J A D Farrell; P-L Bazin; S K Farrell; J N Ratchford; P A Calabresi; D S Reich Journal: Neurology Date: 2011-01-11 Impact factor: 9.910
Authors: Daniel M Harrison; Navid Shiee; Pierre-Louis Bazin; Scott D Newsome; John N Ratchford; Dzung Pham; Peter A Calabresi; Daniel S Reich Journal: J Neurol Date: 2012-08-12 Impact factor: 4.849
Authors: C Guglielmetti; J Veraart; E Roelant; Z Mai; J Daans; J Van Audekerke; M Naeyaert; G Vanhoutte; R Delgado Y Palacios; J Praet; E Fieremans; P Ponsaerts; J Sijbers; A Van der Linden; M Verhoye Journal: Neuroimage Date: 2015-10-23 Impact factor: 6.556
Authors: Ilona Lipp; Derek K Jones; Sonya Bells; Eleonora Sgarlata; Catherine Foster; Rachael Stickland; Alison E Davidson; Emma C Tallantyre; Neil P Robertson; Richard G Wise; Valentina Tomassini Journal: Hum Brain Mapp Date: 2019-03-19 Impact factor: 5.038