PURPOSE: To evaluate the reproducibility and gender differences in cerebrovascular reactivity (CVR) measurements obtained using the blood-oxygen level dependent (BOLD) response to controlled changes in end-tidal partial pressure of carbon dioxide (PETCO(2)). MATERIALS AND METHODS: We obtained ethical approval to image 19 healthy volunteers (10 men, 9 women) on a 1.5 Tesla (T) MRI scanner twice on two separate days using identical procedures. CVR images were generated by collecting BOLD MRI data during controlled changes in PETCO(2) induced by a sequential gas delivery system. RESULTS: Using the intraclass correlation coefficient (ICC), we demonstrated excellent within-day CVR measures in gray matter (GM) (ICC = 0.92) and white matter (WM) (ICC = 0.88) regions, excellent between-day reproducibility in GM (ICC = 0.81), and good between-day reproducibility in the WM (ICC = 0.66). CVR values between men and women were significantly different in the GM and WM. Men exhibited a 22 +/- 2% greater CVR in GM and a 17 +/- 2% greater CVR in WM compared with females. CONCLUSION: Our results demonstrate the reliability of BOLD MRI CVR measurements obtained using a controlled cerebrovascular challenge. Using this technique, we also revealed significantly increased BOLD response to CO(2) in males compared with females.
PURPOSE: To evaluate the reproducibility and gender differences in cerebrovascular reactivity (CVR) measurements obtained using the blood-oxygen level dependent (BOLD) response to controlled changes in end-tidal partial pressure of carbon dioxide (PETCO(2)). MATERIALS AND METHODS: We obtained ethical approval to image 19 healthy volunteers (10 men, 9 women) on a 1.5 Tesla (T) MRI scanner twice on two separate days using identical procedures. CVR images were generated by collecting BOLD MRI data during controlled changes in PETCO(2) induced by a sequential gas delivery system. RESULTS: Using the intraclass correlation coefficient (ICC), we demonstrated excellent within-day CVR measures in gray matter (GM) (ICC = 0.92) and white matter (WM) (ICC = 0.88) regions, excellent between-day reproducibility in GM (ICC = 0.81), and good between-day reproducibility in the WM (ICC = 0.66). CVR values between men and women were significantly different in the GM and WM. Men exhibited a 22 +/- 2% greater CVR in GM and a 17 +/- 2% greater CVR in WM compared with females. CONCLUSION: Our results demonstrate the reliability of BOLD MRI CVR measurements obtained using a controlled cerebrovascular challenge. Using this technique, we also revealed significantly increased BOLD response to CO(2) in males compared with females.
Authors: Varsha Jain; Michael C Langham; Thomas F Floyd; Gaurav Jain; Jeremy F Magland; Felix W Wehrli Journal: J Cereb Blood Flow Metab Date: 2011-04-20 Impact factor: 6.200
Authors: DaiWai M Olson; W Andrew Kofke; Kristine O'Phelan; Puneet K Gupta; Stephen A Figueroa; Stelios M Smirnakis; Peter D Leroux; Jose I Suarez Journal: Neurocrit Care Date: 2015-06 Impact factor: 3.210
Authors: Otto M Henriksen; Christina Kruuse; Jes Olesen; Lars T Jensen; Henrik B W Larsson; Steffen Birk; Jakob M Hansen; Troels Wienecke; Egill Rostrup Journal: J Cereb Blood Flow Metab Date: 2013-02-13 Impact factor: 6.200
Authors: William Reginold; Kevin Sam; Julien Poublanc; Joe Fisher; Adrian Crawley; David J Mikulis Journal: Hum Brain Mapp Date: 2019-05-21 Impact factor: 5.038
Authors: Alexander J Lin; Gangjun Liu; Nicholas A Castello; James J Yeh; Rombod Rahimian; Grace Lee; Victoria Tsay; Anthony J Durkin; Bernard Choi; Frank M LaFerla; Zhongping Chen; Kim N Green; Bruce J Tromberg Journal: Neurophotonics Date: 2014-07 Impact factor: 3.593
Authors: C A C Wijman; S M Smirnakis; P Vespa; K Szigeti; W C Ziai; M M Ning; J Rosand; D F Hanley; R Geocadin; C Hall; P D Le Roux; J I Suarez; O O Zaidat Journal: Neurocrit Care Date: 2012-02 Impact factor: 3.210