Literature DB >> 20097439

The role of protozoa-driven selection in shaping human genetic variability.

Uberto Pozzoli1, Matteo Fumagalli, Rachele Cagliani, Giacomo P Comi, Nereo Bresolin, Mario Clerici, Manuela Sironi.   

Abstract

Protozoa exert a strong selective pressure in humans. The selection signatures left by these pathogens can be exploited to identify genetic modulators of infection susceptibility. We show that protozoa diversity in different geographic locations is a good measure of protozoa-driven selective pressure; protozoa diversity captured selection signatures at known malaria resistance loci and identified several selected single nucleotide polymorphisms in immune and hemolytic anemia genes. A genome-wide search enabled us to identify 5180 variants mapping to 1145 genes that are subjected to protozoa-driven selective pressure. We provide a genome-wide estimate of protozoa-driven selective pressure and identify candidate susceptibility genes for protozoa-borne diseases. Copyright 2010 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Year:  2010        PMID： 20097439     DOI： 10.1016/j.tig.2009.12.010

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  17 in total

1.  An evolutionary history of the selectin gene cluster in humans.

Authors:  M Fumagalli; M Fracassetti; R Cagliani; D Forni; U Pozzoli; G P Comi; F Marini; N Bresolin; M Clerici; M Sironi
Journal:  Heredity (Edinb)       Date:  2012-05-02       Impact factor: 3.821

2.  Evolution of the rapidly mutating human salivary agglutinin gene (DMBT1) and population subsistence strategy.

Authors:  Shamik Polley; Sandra Louzada; Diego Forni; Manuela Sironi; Theodosius Balaskas; David S Hains; Fengtang Yang; Edward J Hollox
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-06       Impact factor: 11.205

3.  Evolutionary history of copy-number-variable locus for the low-affinity Fcγ receptor: mutation rate, autoimmune disease, and the legacy of helminth infection.

Authors:  Lee R Machado; Robert J Hardwick; Jennifer Bowdrey; Helen Bogle; Timothy J Knowles; Manuela Sironi; Edward J Hollox
Journal:  Am J Hum Genet       Date:  2012-05-17       Impact factor: 11.025

4.  Analysis of five deep-sequenced trio-genomes of the Peninsular Malaysia Orang Asli and North Borneo populations.

Authors:  Lian Deng; Haiyi Lou; Xiaoxi Zhang; Bhooma Thiruvahindrapuram; Dongsheng Lu; Christian R Marshall; Chang Liu; Bo Xie; Wanxing Xu; Lai-Ping Wong; Chee-Wei Yew; Aghakhanian Farhang; Rick Twee-Hee Ong; Mohammad Zahirul Hoque; Abdul Rahman Thuhairah; Bhak Jong; Maude E Phipps; Stephen W Scherer; Yik-Ying Teo; Subbiah Vijay Kumar; Boon-Peng Hoh; Shuhua Xu
Journal:  BMC Genomics       Date:  2019-11-12       Impact factor: 3.969

5.  Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia.

Authors:  Xuanyao Liu; Yushimah Yunus; Dongsheng Lu; Farhang Aghakhanian; Woei-Yuh Saw; Lian Deng; Mohammad Ali; Xu Wang; Fadzilah Mohd Nor; Fadzilah Ghazali; Thuhairah Abdul Rahman; Shahrul Azlin Shaari; Mohd Zaki Salleh; Maude E Phipps; Rick Twee-Hee Ong; Shuhua Xu; Yik-Ying Teo; Boon-Peng Hoh
Journal:  Hum Genet       Date:  2015-01-30       Impact factor: 5.881

6.  A -436C>A polymorphism in the human FAS gene promoter associated with severe childhood malaria.

Authors:  Kathrin Schuldt; Cosima C Kretz; Christian Timmann; Jürgen Sievertsen; Christa Ehmen; Claudia Esser; Wibke Loag; Daniel Ansong; Carmen Dering; Jennifer Evans; Andreas Ziegler; Jürgen May; Peter H Krammer; Tsiri Agbenyega; Rolf D Horstmann
Journal:  PLoS Genet       Date:  2011-05-19       Impact factor: 5.917

7.  Pathogen-driven selection in the human genome.

Authors:  Rachele Cagliani; Manuela Sironi
Journal:  Int J Evol Biol       Date:  2013-03-04

8.  A proximity-based method to identify genomic regions correlated with a continuously varying environmental variable.

Authors:  Cornelia Di Gaetano; Giuseppe Matullo; Alberto Piazza; Moreno Ursino; Mauro Gasparini
Journal:  Evol Bioinform Online       Date:  2013-01-29       Impact factor: 1.625

9.  Association between immunoglobulin GM and KM genotypes and placental malaria in HIV-1 negative and positive women in western Kenya.

Authors:  Nnaemeka C Iriemenam; Janardan P Pandey; John Williamson; Anna J Blackstock; Ajay Yesupriya; Aryan M Namboodiri; Keith M Rocca; Anna Maria van Eijk; John Ayisi; Juliana Oteino; Renu B Lal; Feiko O ter Kuile; Richard Steketee; Bernard Nahlen; Laurence Slutsker; Ya Ping Shi
Journal:  PLoS One       Date:  2013-01-11       Impact factor: 3.240

10.  Race and gender variation in response to evoked inflammation.

Authors:  Jane F Ferguson; Parth N Patel; Rhia Y Shah; Claire K Mulvey; Ram Gadi; Prabhjot S Nijjar; Haris M Usman; Nehal N Mehta; Rachana Shah; Stephen R Master; Kathleen J Propert; Muredach P Reilly
Journal:  J Transl Med       Date:  2013-03-12       Impact factor: 5.531
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.