Literature DB >> 20097232

Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat.

Osei B Ansah1, Nora Bourbia, Leonor Gonçalves, Armando Almeida, Antti Pertovaara.   

Abstract

The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.

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Year:  2010        PMID： 20097232     DOI： 10.1016/j.bbr.2010.01.021

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  23 in total

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Authors:  Volker Neugebauer
Journal:  Handb Exp Pharmacol       Date:  2015

2.  NMDA or non-NMDA receptor antagonism within the amygdaloid central nucleus suppresses the affective dimension of pain in rats: evidence for hemispheric synergy.

Authors:  Catherine A Spuz; George S Borszcz
Journal:  J Pain       Date:  2012-03-15       Impact factor: 5.820

3.  Long-term changes in reward-seeking following morphine withdrawal are associated with altered N-methyl-D-aspartate receptor 1 splice variants in the amygdala.

Authors:  E M Anderson; J K Neubert; R M Caudle
Journal:  Neuroscience       Date:  2012-08-02       Impact factor: 3.590

4.  Persistent neuropathic pain increases synaptic GluA1 subunit levels in core and shell subregions of the nucleus accumbens.

Authors:  Duo Xu; Chen Su; Hau-Yueh Lin; Toby Manders; Jing Wang
Journal:  Neurosci Lett       Date:  2015-10-22       Impact factor: 3.046

5.  Differential effects of mGluR7 and mGluR8 activation on pain-related synaptic activity in the amygdala.

Authors:  Wenjie Ren; Enza Palazzo; Sabatino Maione; Volker Neugebauer
Journal:  Neuropharmacology       Date:  2011-08-16       Impact factor: 5.250

6.  The left central nucleus of the amygdala contributes to mechanical allodynia and hyperalgesia following right-sided peripheral nerve injury.

Authors:  Andrew H Cooper; Jennifer J Brightwell; Naomi S Hedden; Bradley K Taylor
Journal:  Neurosci Lett       Date:  2018-08-13       Impact factor: 3.046

7.  Amygdala physiology in pain.

Authors:  Volker Neugebauer
Journal:  Handb Behav Neurosci       Date:  2020-03-31

8.  Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior.

Authors:  Zhen Li; Guangchen Ji; Volker Neugebauer
Journal:  J Neurosci       Date:  2011-01-19       Impact factor: 6.167

Review 9.  Neural mechanisms of pain and alcohol dependence.

Authors:  A Vania Apkarian; Volker Neugebauer; George Koob; Scott Edwards; Jon D Levine; Luiz Ferrari; Mark Egli; Soundar Regunathan
Journal:  Pharmacol Biochem Behav       Date:  2013-10-02       Impact factor: 3.533

10.  Central sensitization of the spino-parabrachial-amygdala pathway that outlasts a brief nociceptive stimulus.

Authors:  Sarah A Kissiwaa; Elena E Bagley
Journal:  J Physiol       Date:  2018-07-13       Impact factor: 5.182
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