Molecular strategies used by fish pathogens to interfere with host-programmed cell death.

Cell death is of pivotal importance in the regulation of the immune response and has a direct impact in disease resistance. Fish are becoming an interesting model organism to study the immune response since they hold a key phylogenetic position and many species are of high economic interest. The role of cell death in the immune response has recently been investigated in fish and the molecules and pathways orchestrating cell death in this group of animals have begun to be elucidated. In this study, we will summarize the different molecular strategies displayed by major fish bacterial and viral pathogens to interfere with programmed cell death of the host as well as the relevance of cell death in the resolution of the infectious diseases caused by these pathogens. Copyright 2010 Elsevier Ltd. All rights reserved.