Literature DB >> 20097068

Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers.

John Lloyd1, Heather J Finlay, Wayne Vacarro, Tram Hyunh, Alexander Kover, Rao Bhandaru, Lin Yan, Karnail Atwal, Mary Lee Conder, Tonya Jenkins-West, Hong Shi, Christine Huang, Danshi Li, Huabin Sun, Paul Levesque.   

Abstract

Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20097068     DOI： 10.1016/j.bmcl.2009.12.085

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Synthesis of novel star-shaped molecules based on a 1,3,5-triazine core linked to different heterocyclic systems as novel hybrid molecules.

Authors:  Hadeer M Diab; Mostafa E Salem; Ismail A Abdelhamid; Ahmed H M Elwahy
Journal:  RSC Adv       Date:  2020-12-14       Impact factor: 4.036

2.  Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I Kur Inhibitor.

Authors:  Heather J Finlay; James A Johnson; John L Lloyd; Ji Jiang; James Neels; Prashantha Gunaga; Abhisek Banerjee; Naveen Dhondi; Anjaneya Chimalakonda; Sandhya Mandlekar; Mary Lee Conder; Harinath Sale; Dezhi Xing; Paul Levesque; Ruth R Wexler
Journal:  ACS Med Chem Lett       Date:  2016-06-09       Impact factor: 4.345

3.  1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors.

Authors:  Vladimir Burmistrov; Christophe Morisseau; Dmitry Danilov; Todd R Harris; Igor Dalinger; Irina Vatsadze; Tatiana Shkineva; Gennady M Butov; Bruce D Hammock
Journal:  Bioorg Med Chem Lett       Date:  2015-10-23       Impact factor: 2.823

4.  Synthesis, crystal structure and antibacterial studies of dihydropyrimidines and their regioselectively oxidized products.

Authors:  Alakbar E Huseynzada; Christian Jelch; Haji Vahid N Akhundzada; Sarra Soudani; Cherif Ben Nasr; Aygun Israyilova; Filippo Doria; Ulviyya A Hasanova; Rana F Khankishiyeva; Mauro Freccero
Journal:  RSC Adv       Date:  2021-02-03       Impact factor: 3.361

5.  Dihydropyrimidinones: efficient one-pot green synthesis using Montmorillonite-KSF and evaluation of their cytotoxic activity.

Authors:  Saleem Farooq; Fahad A Alharthi; Ali Alsalme; Aashiq Hussain; Bashir A Dar; Abid Hamid; S Koul
Journal:  RSC Adv       Date:  2020-11-23       Impact factor: 4.036

Review 6.  Challenges Faced with Small Molecular Modulators of Potassium Current Channel Isoform Kv1.5.

Authors:  Zefeng Zhao; Songsong Ruan; Xiaoming Ma; Qian Feng; Zhuosong Xie; Zhuang Nie; Peinan Fan; Mingcheng Qian; Xirui He; Shaoping Wu; Yongmin Zhang; Xiaohui Zheng
Journal:  Biomolecules       Date:  2019-12-19
  6 in total

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