| Literature DB >> 20097066 |
Vinod R Hegde1, Scott Borges, Haiyan Pu, Mahesh Patel, Vincent P Gullo, Bonnie Wu, Paul Kirschmeier, Michael J Williams, Vincent Madison, Thierry Fischmann, Tze-Ming Chan.
Abstract
Several analogs of aristolochic acids were isolated and derivatized into their lactam derivatives to study their inhibition in CDK2 assay. The study helped to derive some conclusions about the structure-activity relation around the phenanthrin moiety. Semi-synthetic aristolactam 21 showed good activity with inhibition IC50 of 35 nM in CDK2 assay. The activity of this compound was comparable to some of the most potent synthetic compounds reported in the literature. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20097066 DOI： 10.1016/j.bmcl.2010.01.007
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823