| Literature DB >> 20096391 |
Ana Vujanic1, Janet L K Wee, Kenneth J Snibson, Stirling Edwards, Martin Pearse, Charles Quinn, Margaret Moloney, Shirley Taylor, Jean-Pierre Y Scheerlinck, Philip Sutton.
Abstract
Deep pulmonary delivery of an influenza ISCOMATRIX vaccine has previously been shown to induce a combined mucosal and systemic antibody response. To explore whether this combined response is influenced by intrinsic properties of the component antigen, we examined the efficacy of deep pulmonary delivery of ISCOMATRIX vaccines containing different recombinant antigens, specifically gB glycoprotein from cytomegalovirus and a fragment of catalase from Helicobacter pylori. Both these vaccines induced antigen-specific mucosal and systemic immunity, as well as antigen-specific proliferative cellular responses. Pulmonary immunisation with ISCOMATRIX vaccines may therefore be a generic way of inducing combined systemic and mucosal immunity. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20096391 DOI： 10.1016/j.vaccine.2010.01.018
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641