| Literature DB >> 20096368 |
Raimund Mannhold1, Simone Fulda, Emanuele Carosati.
Abstract
A promising strategy in cancer therapy aims to promote apoptosis in cancer cells. Targeting inhibitor of apoptosis proteins (IAPs) with small-molecule inhibitors has attracted increasing interest in triggering cancer cell death. It is considered to have great potential for cancer drug discovery because IAPs block apoptosis at the core of the apoptotic machinery and are aberrantly expressed in various tumors. This review focuses on the current development of small-molecule IAP antagonists for cancer therapy. 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20096368 DOI： 10.1016/j.drudis.2010.01.003
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851