Literature DB >> 20095572

First efficient synthesis of fluorinated glycidic esters from ketones.

Gérald Lemonnier1, Ludivine Zoute, Jean-Charles Quirion, Philippe Jubault.   

Abstract

Treatment of various ketones with ethyl dibromofluoroacetate in the presence of diethylzinc and dimethylaminoethanol or triphenylphosphine provides rapid access to corresponding fluorinated glycidic esters. Simplified workup allowed first characterization of these compounds.

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Year:  2010        PMID: 20095572     DOI: 10.1021/ol902903v

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

Review 1.  Ethyl dibromofluoroacetate: a versatile reagent for the synthesis of fluorinated molecules.

Authors:  Emilie David; Samuel Couve-Bonnaire; Philippe Jubault; Xavier Pannecoucke
Journal:  Tetrahedron       Date:  2013-10-21       Impact factor: 2.457

2.  Diastereoselective synthesis of 2-fluoroaziridine-2-carboxylates by Reformatsky-type aza-Darzens reaction.

Authors:  Atsushi Tarui; Naoto Kawashima; Kazuyuki Sato; Masaaki Omote; Akira Ando
Journal:  Tetrahedron Lett       Date:  2010-06-11       Impact factor: 2.415

  2 in total

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