| Literature DB >> 20094051 |
Carine Rosse1, Mark Linch, Stéphanie Kermorgant, Angus J M Cameron, Katrina Boeckeler, Peter J Parker.
Abstract
Networks of signal transducers determine the conversion of environmental cues into cellular actions. Among the main players in these networks are protein kinases, which can acutely and reversibly modify protein functions to influence cellular events. One group of kinases, the protein kinase C (PKC) family, have been increasingly implicated in the organization of signal propagation, particularly in the spatial distribution of signals. Examples of where and how various PKC isoforms direct this tier of signal organization are becoming more evident.Entities:
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Year: 2010 PMID： 20094051 DOI： 10.1038/nrm2847
Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444