| Literature DB >> 20093784 |
Satoshi Miyauchi1, Akira Hirasawa, Atsuhiko Ichimura, Takafumi Hara, Gozoh Tsujimoto.
Abstract
Utilizing the human genome database, the recently developed G-protein-coupled receptors (GPCRs) deorphanizing strategy successfully identified multiple receptors of free fatty acids (FFAs). FFAs have been demonstrated to act as ligands of several GPCRs (FFAR1, FFAR2, FFAR3, and GPR120). These fatty acid receptors are proposed to play critical roles in various types of physiological homeostases. FFAR1 and GPR120 are activated by medium- and long-chain FFAs. In contrast, FFAR2 and FFAR3 are activated by short-chain FFAs. It has been elucidated that these four receptors are expressed in the gastrointestinal tract and have many essential roles as sensors of FFA. In this review, we summarize the physiological and pharmacological function of the receptors in the gastrointestinal tract.Entities:
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Year: 2010 PMID： 20093784 DOI： 10.1254/jphs.09r09fm
Source DB: PubMed Journal: J Pharmacol Sci ISSN： 1347-8613 Impact factor: 3.337