Literature DB >> 20093726

Calcineurin/NFAT signaling in lymphoid malignancies.

Stephanie Gachet1, Jacques Ghysdael.   

Abstract

Deregulated calcium signaling is observed at different stages of tumorigenic processes. An important signaling pathway activated in response to calcium involves the protein phosphatase calcineurin and NFAT transcriptional factors. We review here recent data that indicate an important role of the calcineurin/NFAT pathway in lymphoma/leukemogenesis and discuss the potential therapeutic implications of these findings.

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Year:  2009        PMID： 20093726

Source DB:  PubMed          Journal:  Gen Physiol Biophys        ISSN： 0231-5882            Impact factor:   1.512


  8 in total

Review 1.  Calcineurin in development and disease.

Authors:  Lei Chen; Min Song; Chunyan Yao
Journal:  Genes Dis       Date:  2021-03-15

2.  Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma.

Authors:  Yoichi Imai; Eri Ohta; Shu Takeda; Satoko Sunamura; Mariko Ishibashi; Hideto Tamura; Yan-Hua Wang; Atsuko Deguchi; Junji Tanaka; Yoshiro Maru; Toshiko Motoji
Journal:  JCI Insight       Date:  2016-04-21

3.  Role of Ca/CaN/NFAT signaling in IL-4 expression by splenic lymphocytes exposed to phthalate (2-ethylhexyl) ester in spleen lymphocytes.

Authors:  Xiucong Pei; Zhiwen Duan; Mingyue Ma; Yuming Zhang; Li Guo
Journal:  Mol Biol Rep       Date:  2014-01-14       Impact factor: 2.316

4.  B-cell receptor-mediated NFATc1 activation induces IL-10/STAT3/PD-L1 signaling in diffuse large B-cell lymphoma.

Authors:  Li Li; Jun Zhang; Juan Chen; Zijun Y Xu-Monette; Yi Miao; Min Xiao; Ken H Young; Sa Wang; L Jeffrey Medeiros; Michael Wang; Richard J Ford; Lan V Pham
Journal:  Blood       Date:  2018-09-12       Impact factor: 22.113

Review 5.  Placing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts.

Authors:  Oxana Dobrovinskaya; Iván Delgado-Enciso; Laura Johanna Quintero-Castro; Carlos Best-Aguilera; Rocío Monserrat Rojas-Sotelo; Igor Pottosin
Journal:  Biomed Res Int       Date:  2015-03-19       Impact factor: 3.411

Review 6.  Action mechanisms of histone deacetylase inhibitors in the treatment of hematological malignancies.

Authors:  Yoichi Imai; Yoshiro Maru; Junji Tanaka
Journal:  Cancer Sci       Date:  2016-11-04       Impact factor: 6.716

Review 7.  Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia.

Authors:  Deborah Bongiovanni; Valentina Saccomani; Erich Piovan
Journal:  Int J Mol Sci       Date:  2017-09-05       Impact factor: 5.923

8.  Inhibitory effects of sigma-2 receptor agonists on T lymphocyte activation.

Authors:  Miguel A Iñiguez; Carmen Punzón; Raquel Nieto; Javier Burgueño; José M Vela; Manuel Fresno
Journal:  Front Pharmacol       Date:  2013-03-13       Impact factor: 5.810
  8 in total

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