| Literature DB >> 20092921 |
Tobias Schulze1, Sara Weiss, Emma Schymanski, Peter Carsten von der Ohe, Mechthild Schmitt-Jansen, Rolf Altenburger, Georg Streck, Werner Brack.
Abstract
The pharmaceutical diclofenac (DCF) is released in considerably high amounts to the aquatic environment. Photo-transformation of DCF was reported as the main degradation pathway in surface waters and was found to produce metabolites with enhanced toxicity to the green algae Scenedesmus vacuolatus. We identified and subsequently confirmed 2-[2-(chlorophenyl)amino]benzaldehyde (CPAB) as a transformation product with enhanced toxicity using effect-directed analysis. The EC(50) of CPAB (4.8 mg/L) was a factor of 10 lower than that for DCF (48.1 mg/L), due to the higher hydrophobicity of CPAB (log K(ow) = 3.62) compared with DCF (log D(ow) = 2.04) at pH 7.0. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20092921 DOI： 10.1016/j.envpol.2009.12.032
Source DB: PubMed Journal: Environ Pollut ISSN： 0269-7491 Impact factor: 8.071