| Literature DB >> 20091830 |
Padma V Devarajan1, Anil B Jindal, Rajesh R Patil, Fernaz Mulla, Rajiv V Gaikwad, Abdul Samad.
Abstract
The role of particle size and surface modification on biodistribution of nanocarriers is widely reported. We report for the first time the role of nanoparticle shape on biodistribution. Our study demonstrates that irregular shaped polymer lipid nanoparticles (LIPOMER) evade kupffer cells and localize in the spleen. We also demonstrate the macrophage-evading characteristic of the irregular-shaped LIPOMER. Our results suggest particle shape as an important tool for passive targeting of nanocarriers in splenotropic drug delivery. (c) 2010 Wiley-Liss, Inc. and the American Pharmacists AssociationEntities:
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Year: 2010 PMID： 20091830 DOI： 10.1002/jps.22052
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534