BACKGROUND: Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several human cancers. METHODS: This study used an immunohistochemical technique to examine the expression of PlGF in 100 specimens of oral squamous cell carcinoma (OSCC). RESULTS: We found that the higher mean PlGF labeling index was significantly associated with OSCCs with positive lymph node metastasis (p = .014) or with more advanced clinical stages (p = .016). Positive lymph node metastasis (p = .008) and PlGF labeling index >40% (p = .010) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, a Kaplan-Meier curve showed that OSCC patients with a PlGF labeling index >40% had a significantly poorer cumulative survival than those with a PlGF labeling index ≤40% (log-rank test, p = .003). CONCLUSIONS: The PlGF labeling index can predict the progression and prognosis of OSCCs in Taiwan.
BACKGROUND: Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several humancancers. METHODS: This study used an immunohistochemical technique to examine the expression of PlGF in 100 specimens of oral squamous cell carcinoma (OSCC). RESULTS: We found that the higher mean PlGF labeling index was significantly associated with OSCCs with positive lymph node metastasis (p = .014) or with more advanced clinical stages (p = .016). Positive lymph node metastasis (p = .008) and PlGF labeling index >40% (p = .010) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, a Kaplan-Meier curve showed that OSCC patients with a PlGF labeling index >40% had a significantly poorer cumulative survival than those with a PlGF labeling index ≤40% (log-rank test, p = .003). CONCLUSIONS: The PlGF labeling index can predict the progression and prognosis of OSCCs in Taiwan.
Authors: Erwin Kristobal Gudenschwager-Basso; Valentina Stevenson; Dan Phillip Sponenberg; Thomas E Cecere; William R Huckle Journal: Vet Sci Date: 2022-07-21
Authors: Vishwajith Sridharan; Danielle N Margalit; Stephanie A Lynch; Mariano Severgnini; F Stephen Hodi; Robert I Haddad; Roy B Tishler; Jonathan D Schoenfeld Journal: J Immunother Cancer Date: 2016-06-21 Impact factor: 13.751