OBJECTIVE: The present study was conducted to assess the utility of serum transferrin receptor (sTfR) and sTfR ferritin indices to differentiate ACD from IDA and also to diagnose coexisting IDA and ACD. METHODS: The study group comprised of 30 IDA patients, 30 cases of ACD and 30 age and sex matched controls. Complete hemogram with peripheral smear examination, markers of ACD, iron profile including serum ferritin and serum transferrin receptor levels were done in all patients and controls. Serum TfR and ferritin indices were calculated. RESULTS: sTfR levels were significantly higher in the IDA group compared to ACD group (p<0.001). ACD group was further subdivided into two groups on the basis of sTfR levels (B1<3 microg/ml and B2 > or = microg/ml), suggesting coexisting IDA in group B2. sTfR/log ferritin index was > 1.5 in all cases of IDA and ACD with coexisting IDA while all pure ACD cases and control subjects had sTfR/log ferritin index < 1.5. All case in IDA group had log sTfR/serum ferritin index > 2.55 and all patients with ACD with or without associated iron deficiency had log sTfR/serum ferritin ratio < 2.55. CONCLUSION: The sTfR levels along with the above mentioned indices can be very useful in differentiating pure IDA, ACD and ACD with coexisting iron deficiency, thus providing a noninvasive alternative to bone marrow iron.
OBJECTIVE: The present study was conducted to assess the utility of serum transferrin receptor (sTfR) and sTfR ferritin indices to differentiate ACD from IDA and also to diagnose coexisting IDA and ACD. METHODS: The study group comprised of 30 IDA patients, 30 cases of ACD and 30 age and sex matched controls. Complete hemogram with peripheral smear examination, markers of ACD, iron profile including serum ferritin and serum transferrin receptor levels were done in all patients and controls. Serum TfR and ferritin indices were calculated. RESULTS: sTfR levels were significantly higher in the IDA group compared to ACD group (p<0.001). ACD group was further subdivided into two groups on the basis of sTfR levels (B1<3 microg/ml and B2 > or = microg/ml), suggesting coexisting IDA in group B2. sTfR/log ferritin index was > 1.5 in all cases of IDA and ACD with coexisting IDA while all pure ACD cases and control subjects had sTfR/log ferritin index < 1.5. All case in IDA group had log sTfR/serum ferritin index > 2.55 and all patients with ACD with or without associated iron deficiency had log sTfR/serum ferritin ratio < 2.55. CONCLUSION: The sTfR levels along with the above mentioned indices can be very useful in differentiating pure IDA, ACD and ACD with coexisting iron deficiency, thus providing a noninvasive alternative to bone marrow iron.
Authors: J L Coenen; M P van Dieijen-Visser; J van Pelt; C T van Deursen; M M Fickers; J W van Wersch; P J Brombacher Journal: Clin Chem Date: 1991-04 Impact factor: 8.327
Authors: M Angeles Vázquez López; Francisco Lendinez Molinos; Moisés Leyva Carmona; Amparo Carracedo Morales; Francisco Javier Muñoz Vico; Juan López Muñoz; Antonio Muñoz Hoyos Journal: J Pediatr Hematol Oncol Date: 2006-12 Impact factor: 1.289
Authors: Sean Lynch; Christine M Pfeiffer; Michael K Georgieff; Gary Brittenham; Susan Fairweather-Tait; Richard F Hurrell; Harry J McArdle; Daniel J Raiten Journal: J Nutr Date: 2018-06-01 Impact factor: 4.798
Authors: R K Chandyo; S Henjum; M Ulak; A L Thorne-Lyman; R J Ulvik; P S Shrestha; L Locks; W Fawzi; T A Strand Journal: Eur J Clin Nutr Date: 2015-12-02 Impact factor: 4.016
Authors: Susan J Fairweather-Tait; Anna A Wawer; Rachel Gillings; Amy Jennings; Phyo K Myint Journal: Mech Ageing Dev Date: 2013-11-22 Impact factor: 5.432