BACKGROUND/AIMS: Little is known about the association of chronic kidney disease (CKD) with sleep quality, mood, and alertness. In this report, we assessed these symptoms among patients with advanced CKD (stages 4-5) and those with end-stage renal disease (ESRD) and compared them to healthy controls without known kidney disease. METHODS: Patients were recruited from local dialysis units, outpatient nephrology clinics and the Thomas E. Starzl Transplant Institute. Healthy control subjects matched for age, gender and race were drawn from an archival database. Daily symptoms of sleep quality, mood, and alertness were assessed by visual analogue scales of the Pittsburgh Sleep Diary. Health-related quality of life was assessed by the Short Form-36 instrument. RESULTS: Sixty-nine dialysis patients and 23patients with advanced CKD demonstrated worse scores in sleep quality, mood, and alertness (p < 0.001) than controls. In adjusted analyses, European-American race, dialysis dependency, younger age, and physical performance SF-36 components were significantly associated with poor sleep quality, mood and alertness (p < 0.05). The dialysis population demonstrated higher day-to-day variability in scores than either the advanced CKD patients or the controls. CONCLUSION: Advanced CKD and dialysis dependency are associated with impaired and highly variable sleep quality, mood, and alertness. Copyright 2010 S. Karger AG, Basel.
BACKGROUND/AIMS: Little is known about the association of chronic kidney disease (CKD) with sleep quality, mood, and alertness. In this report, we assessed these symptoms among patients with advanced CKD (stages 4-5) and those with end-stage renal disease (ESRD) and compared them to healthy controls without known kidney disease. METHODS:Patients were recruited from local dialysis units, outpatient nephrology clinics and the Thomas E. Starzl Transplant Institute. Healthy control subjects matched for age, gender and race were drawn from an archival database. Daily symptoms of sleep quality, mood, and alertness were assessed by visual analogue scales of the Pittsburgh Sleep Diary. Health-related quality of life was assessed by the Short Form-36 instrument. RESULTS: Sixty-nine dialysis patients and 23patients with advanced CKD demonstrated worse scores in sleep quality, mood, and alertness (p < 0.001) than controls. In adjusted analyses, European-American race, dialysis dependency, younger age, and physical performance SF-36 components were significantly associated with poor sleep quality, mood and alertness (p < 0.05). The dialysis population demonstrated higher day-to-day variability in scores than either the advanced CKDpatients or the controls. CONCLUSION: Advanced CKD and dialysis dependency are associated with impaired and highly variable sleep quality, mood, and alertness. Copyright 2010 S. Karger AG, Basel.
Authors: Helena Levitt; Annette Wood; Douglas E Moul; Martica Hall; Anne Germain; David J Kupfer; Daniel J Buysse Journal: Behav Sleep Med Date: 2004 Impact factor: 2.964
Authors: Khaled Abdel-Kader; Manisha Jhamb; Lee Anne Mandich; Jonathan Yabes; Robert M Keene; Scott Beach; Daniel J Buysse; Mark L Unruh Journal: BMC Nephrol Date: 2014-02-06 Impact factor: 2.388
Authors: Pasquale Esposito; Francesco Furini; Teresa Rampino; Marilena Gregorini; Lucia Petrucci; Catherine Klersy; Antonio Dal Canton; Elena Dalla Toffola Journal: Clin Kidney J Date: 2016-11-10