Literature DB >> 2008993

Effect of prednisolone treatment in chronic silicosis.

S K Sharma1, J N Pande, K Verma.   

Abstract

We evaluated the effects of daily oral prednisolone therapy on alveolitis parameters and pulmonary function tests over a 6-month period in patients with chronic silicosis. Pulmonary function tests were done in 34 patients, and bronchoalveolar lavage (BAL) was done in 21 of them. Pulmonary function tests showed a significant improvement in lung volumes, FEV1, PEFR, SGaw, DLCO, and PaO2. Analysis of BAL fluid revealed a significant decrease in total cell count. Mean fibronectin and immunoglobulin values in BAL fluid also were lower after treatment, but the change was not statistically significant. No serious side effects were encountered with prednisolone therapy. These results indicate that daily oral prednisolone therapy may suppress the alveolitis in certain patients with chronic silicosis and bring about a significant improvement in lung functions and gas exchange.

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Year:  1991        PMID： 2008993     DOI： 10.1164/ajrccm/143.4_Pt_1.814

Source DB:  PubMed          Journal:  Am Rev Respir Dis        ISSN： 0003-0805


  6 in total

1.  Burst abdomen: an unusual complication of silicosis in pregnancy.

Authors:  Gajatheepan Sivabalasubramaniam; Haritha Sagili; Papa Dasari; Mamatha Gowda
Journal:  BMJ Case Rep       Date:  2015-06-24

2.  Intranasal Flunisolide Suppresses Pathological Alterations Caused by Silica Particles in the Lungs of Mice.

Authors:  Tatiana Paula Teixeira Ferreira; Januário Gomes Mourão E Lima; Francisco Alves Farias-Filho; Yago Amigo Pinho Jannini de Sá; Ana Carolina Santos de Arantes; Fernanda Verdini Guimarães; Vinicius de Frias Carvalho; Cory Hogaboam; John Wallace; Marco Aurélio Martins; Patrícia Machado Rodrigues E Silva
Journal:  Front Endocrinol (Lausanne)       Date:  2020-06-17       Impact factor: 5.555

Review 3.  Silicosis and lung cancer: current perspectives.

Authors:  Takashi Sato; Takeshi Shimosato; Dennis M Klinman
Journal:  Lung Cancer (Auckl)       Date:  2018-10-26

4.  Management of interstitial lung diseases: A consensus statement of the Indian Chest Society (ICS) and National College of Chest Physicians (NCCP).

Authors:  Sheetu Singh; Bharat Bhushan Sharma; Mohan Bairwa; Dipti Gothi; Unnati Desai; Jyotsna M Joshi; Deepak Talwar; Abhijeet Singh; Raja Dhar; Ambika Sharma; Bineet Ahluwalia; Daya K Mangal; Nirmal K Jain; Khushboo Pilania; Vijay Hadda; Parvaiz A Koul; Shanti Kumar Luhadia; Rajesh Swarnkar; Shailender Nath Gaur; Aloke G Ghoshal; Amita Nene; Arpita Jindal; Bhavin Jankharia; Chetambath Ravindran; Dhruv Choudhary; Digambar Behera; D J Christopher; Gopi C Khilnani; Jai Kumar Samaria; Harpreet Singh; Krishna Bihari Gupta; Manju Pilania; Manohar L Gupta; Narayan Misra; Nishtha Singh; Prahlad R Gupta; Prashant N Chhajed; Raj Kumar; Rajesh Chawla; Rajendra K Jenaw; Rakesh Chawla; Randeep Guleria; Ritesh Agarwal; R Narsimhan; Sandeep Katiyar; Sanjeev Mehta; Sahajal Dhooria; Sushmita R Chowdhury; Surinder K Jindal; Subodh K Katiyar; Sudhir Chaudhri; Neeraj Gupta; Sunita Singh; Surya Kant; Zarir Udwadia; Virendra Singh; Ganesh Raghu
Journal:  Lung India       Date:  2020 Jul-Aug

Review 5.  Occupational lung disease: A narrative review of lung conditions from the workplace.

Authors:  Mohd Iskandar Jumat; Firdaus Hayati; Syed Sharizman Syed Abdul Rahim; Sahipudin Saupin; Khamisah Awang Lukman; Mohammad Saffree Jeffree; Helen Benedict Lasimbang; Fairrul Kadir
Journal:  Ann Med Surg (Lond)       Date:  2021-03-23

Review 6.  Cell-Based Therapy for Silicosis.

Authors:  Miquéias Lopes-Pacheco; Elga Bandeira; Marcelo M Morales
Journal:  Stem Cells Int       Date:  2016-03-15       Impact factor: 5.443
  6 in total

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