Literature DB >> 20088695

Nonresponder patients with hepatitis C virus genotype 2/3 infection: a question of low systemic interferon concentrations?

Asa Alsiö1, Peer Brehm Christensen, Martti Färkkilä, Nina Langeland, Mads Rauning Buhl, Court Pedersen, Kristine Mørch, Bart L Haagmans, Johan Westin, Kristoffer Hellstrand, Gunnar Norkrans, Martin Lagging.   

Abstract

Twelve of 303 per-protocol patients were nonresponders in a 12-week versus 24-week treatment study of hepatitis C virus (HCV) genotype 2/3 infection. The nonresponders had significantly lower interferon concentrations, as well as significantly greater mean age, body mass index, and viral load. Suboptimal drug concentrations may thus contribute to lack of response to therapy in patients with infection due to HCV genotype 2/3.

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Year:  2010        PMID: 20088695     DOI: 10.1086/650006

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN: 1058-4838            Impact factor:   9.079


  1 in total

1.  Response to peginterferon-alfa 2b and ribavirin in Japanese patients with chronic hepatitis C genotype 2.

Authors:  Tatsuo Kanda; Fumio Imazeki; Ryosaku Azemoto; Yutaka Yonemitsu; Shigeru Mikami; Kazuhiko Kita; Motohide Takashi; Masahiko Sunaga; Shuang Wu; Shingo Nakamoto; Akinobu Tawada; Makoto Arai; Keizo Kato; Yu Yoshida; Yoshihiro Koma; Keiichi Fujiwara; Kenichi Fukai; Noriaki Suzuki; Osamu Yokosuka
Journal:  Dig Dis Sci       Date:  2011-05-22       Impact factor: 3.199

  1 in total

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