Literature DB >> 20085730

Clking on PGC-1alpha to inhibit gluconeogenesis.

Carles Cantó1, Johan Auwerx.   

Abstract

The link between Akt activation and gluconeogenic repression remains unclear, despite many years of investigation and remarkable progress. Rodgers and colleagues now introduce us to the Clk2 kinase, an Akt substrate that can directly phosphorylate and inhibit PGC-1alpha, blunting hepatic glucose production.

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Year:  2010        PMID： 20085730      PMCID： PMC3616263          DOI： 10.1016/j.cmet.2009.12.003

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  8 in total

1.  GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha.

Authors:  Carles Lerin; Joseph T Rodgers; Dario E Kalume; Seung-hee Kim; Akhilesh Pandey; Pere Puigserver
Journal:  Cell Metab       Date:  2006-06       Impact factor: 27.287

Review 2.  Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways.

Authors:  Joseph T Rodgers; Carles Lerin; Zachary Gerhart-Hines; Pere Puigserver
Journal:  FEBS Lett       Date:  2007-11-26       Impact factor: 4.124

3.  A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.

Authors:  P Puigserver; Z Wu; C W Park; R Graves; M Wright; B M Spiegelman
Journal:  Cell       Date:  1998-03-20       Impact factor: 41.582

4.  Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

Authors:  Joseph T Rodgers; Carlos Lerin; Wilhelm Haas; Steven P Gygi; Bruce M Spiegelman; Pere Puigserver
Journal:  Nature       Date:  2005-03-03       Impact factor: 49.962

5.  AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.

Authors:  Carles Cantó; Zachary Gerhart-Hines; Jerome N Feige; Marie Lagouge; Lilia Noriega; Jill C Milne; Peter J Elliott; Pere Puigserver; Johan Auwerx
Journal:  Nature       Date:  2009-04-23       Impact factor: 49.962

6.  Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.

Authors:  Pere Puigserver; James Rhee; Jerry Donovan; Christopher J Walkey; J Cliff Yoon; Francesco Oriente; Yukari Kitamura; Jennifer Altomonte; Hengjiang Dong; Domenico Accili; Bruce M Spiegelman
Journal:  Nature       Date:  2003-05-18       Impact factor: 49.962

7.  Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.

Authors:  Xinghai Li; Bobby Monks; Qingyuan Ge; Morris J Birnbaum
Journal:  Nature       Date:  2007-06-06       Impact factor: 49.962

8.  The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

Authors:  K Colwill; T Pawson; B Andrews; J Prasad; J L Manley; J C Bell; P I Duncan
Journal:  EMBO J       Date:  1996-01-15       Impact factor: 11.598
  8 in total
  4 in total

1.  Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals.

Authors:  Christina T Teng; Burton Beames; B Alex Merrick; Negin Martin; Charles Romeo; Anton M Jetten
Journal:  Biochem Biophys Res Commun       Date:  2014-01-20       Impact factor: 3.575

2.  The KLF14 transcription factor regulates hepatic gluconeogenesis in mice.

Authors:  Lu Wang; Xin Tong; Fang Gu; Lei Zhang; Wei Chen; Xiaowen Cheng; Liwei Xie; Yongsheng Chang; Huabing Zhang
Journal:  J Biol Chem       Date:  2017-11-09       Impact factor: 5.157

3.  Comparative Analysis of MicroRNA and mRNA Profiles of Sperm with Different Freeze Tolerance Capacities in Boar (Sus scrofa) and Giant Panda (Ailuropoda melanoleuca).

Authors:  Ming-Xia Ran; Ying-Min Zhou; Kai Liang; Wen-Can Wang; Yan Zhang; Ming Zhang; Jian-Dong Yang; Guang-Bin Zhou; Kai Wu; Cheng-Dong Wang; Yan Huang; Bo Luo; Izhar Hyder Qazi; He-Min Zhang; Chang-Jun Zeng
Journal:  Biomolecules       Date:  2019-09-01

4.  NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.

Authors:  Raffaele Cerutti; Eija Pirinen; Costanza Lamperti; Silvia Marchet; Anthony A Sauve; Wei Li; Valerio Leoni; Eric A Schon; Françoise Dantzer; Johan Auwerx; Carlo Viscomi; Massimo Zeviani
Journal:  Cell Metab       Date:  2014-05-08       Impact factor: 27.287
  4 in total

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