Literature DB >> 20085700

Aire, master of many trades.

Bruno Kyewski1, Pärt Peterson.   

Abstract

In thymic epithelial cells, the protein Aire (autoimmune regulator) induces the ectopic expression of hundreds of peripheral tissue antigens, thus enlarging the repertoire of antigens available for the induction of central T cell tolerance. By analyzing Aire's interacting partners, Abramson et al. (2010) shed new light on this unorthodox form of gene expression.

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Year:  2010        PMID： 20085700     DOI： 10.1016/j.cell.2009.12.036

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  14 in total

1.  Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression.

Authors:  Samantha M Bonner; Susan L Pietropaolo; Yong Fan; Yigang Chang; Praveen Sethupathy; Michael P Morran; Megan Beems; Nick Giannoukakis; Giuliana Trucco; Michael O Palumbo; Michele Solimena; Alberto Pugliese; Constantin Polychronakos; Massimo Trucco; Massimo Pietropaolo
Journal:  J Biol Chem       Date:  2012-03-24       Impact factor: 5.157

2.  Clinical characteristics of autoimmune disorders in the central nervous system associated with myasthenia gravis.

Authors:  Kimitoshi Kimura; Yoichiro Okada; Chihiro Fujii; Kenichi Komatsu; Ryosuke Takahashi; Sadayuki Matsumoto; Takayuki Kondo
Journal:  J Neurol       Date:  2019-07-24       Impact factor: 4.849

3.  Unusual timing of CD127 expression by mouse uterine natural killer cells.

Authors:  Jianhong Zhang; Zhilin Chen; Jörg H Fritz; Yrina Rochman; Warren J Leonard; Jennifer L Gommerman; Adam W Plumb; Ninan Abraham; B Anne Croy
Journal:  J Leukoc Biol       Date:  2012-01-06       Impact factor: 4.962

4.  Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner.

Authors:  Qiuming He; Y Maurice Morillon; Nicholas A Spidale; Charles J Kroger; Bo Liu; R Balfour Sartor; Bo Wang; Roland Tisch
Journal:  J Immunol       Date:  2013-11-06       Impact factor: 5.422

5.  Compromised central tolerance of ICA69 induces multiple organ autoimmunity.

Authors:  Yong Fan; Giulio Gualtierotti; Asako Tajima; Maria Grupillo; Antonina Coppola; Jing He; Suzanne Bertera; Gregory Owens; Massimo Pietropaolo; William A Rudert; Massimo Trucco
Journal:  J Autoimmun       Date:  2014-08-01       Impact factor: 7.094

6.  Functional Domains of Autoimmune Regulator (AIRE) Modulate INS-VNTR Transcription in Human Thymic Epithelial Cells.

Authors:  Avis E Sparks; Chiachen Chen; Mary B Breslin; Michael S Lan
Journal:  J Biol Chem       Date:  2016-04-05       Impact factor: 5.157

Review 7.  Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development.

Authors:  Konstantina Alexandropoulos; Nichole M Danzl
Journal:  Immunol Res       Date:  2012-12       Impact factor: 4.505

8.  Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirpα+ dendritic cells: a murine model.

Authors:  Tomohisa Baba; Mohamed El Sherif Badr; Utano Tomaru; Akihiro Ishizu; Naofumi Mukaida
Journal:  PLoS One       Date:  2012-07-16       Impact factor: 3.240

Review 9.  Maturation and migration of murine CD4 single positive thymocytes and thymic emigrants.

Authors:  Xi Xu; Qing Ge
Journal:  Comput Struct Biotechnol J       Date:  2014-03-30       Impact factor: 7.271

10.  Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells.

Authors:  Ernna H Oliveira; Claudia Macedo; Cristhianna V Collares; Ana Carolina Freitas; Paula Barbim Donate; Elza T Sakamoto-Hojo; Eduardo A Donadi; Geraldo A Passos
Journal:  Front Immunol       Date:  2016-11-23       Impact factor: 7.561
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