OBJECTIVES: To explore cardiovascular autonomic regulation in Spinocerebellar ataxia type 2 (SCA2) patients, using heart rate variability (HRV) analysis and neurophysiologic autonomic reflex tests, and determine relations and causal related factors of dysautonomia in SCA2. MATERIALS AND METHODS: Heart rate variability indices for 5 min series of RR intervals were analyzed in 97 SCA2 patients, assessed quantitatively for somatic and autonomic nervous system complaints applying the International Cooperative Ataxia Rating Scale and Scales for Outcomes in Parkinson's disease (SCOPA-AUT), respectively. Autonomic testing included: resting control, standing, Valsalva maneuver and deep breathing. RESULTS: Mean RR, long- and short-term variability indices and spectral density power (LF, HF) indices were lower in the patients group, whereas LF/HF ratio and LF (nu) were higher. Highly differences between groups were observed for seven diagnostic autonomic test indices. Significant correlations were found between different clinical and demographic indices and between clinical indices and some HRV indices. CONCLUSIONS: We confirm the presence of cardiovascular autonomic dysfunction in a large group of SCA2 patients.
OBJECTIVES: To explore cardiovascular autonomic regulation in Spinocerebellar ataxia type 2 (SCA2) patients, using heart rate variability (HRV) analysis and neurophysiologic autonomic reflex tests, and determine relations and causal related factors of dysautonomia in SCA2. MATERIALS AND METHODS: Heart rate variability indices for 5 min series of RR intervals were analyzed in 97 SCA2patients, assessed quantitatively for somatic and autonomic nervous system complaints applying the International Cooperative Ataxia Rating Scale and Scales for Outcomes in Parkinson's disease (SCOPA-AUT), respectively. Autonomic testing included: resting control, standing, Valsalva maneuver and deep breathing. RESULTS: Mean RR, long- and short-term variability indices and spectral density power (LF, HF) indices were lower in the patients group, whereas LF/HF ratio and LF (nu) were higher. Highly differences between groups were observed for seven diagnostic autonomic test indices. Significant correlations were found between different clinical and demographic indices and between clinical indices and some HRV indices. CONCLUSIONS: We confirm the presence of cardiovascular autonomic dysfunction in a large group of SCA2patients.
Authors: A R Paciorkowski; Y Shafrir; J Hrivnak; M C Patterson; M B Tennison; H B Clark; C M Gomez Journal: Neurology Date: 2011-08-31 Impact factor: 9.910
Authors: Elisabetta Indelicato; Alessandra Fanciulli; Jean Pierre Ndayisaba; Wolfgang Nachbauer; Roberta Granata; Julia Wanschitz; Michaela Wagner; Elke R Gizewski; Werner Poewe; Gregor K Wenning; Sylvia Boesch Journal: Clin Auton Res Date: 2018-02-12 Impact factor: 4.435
Authors: Alhassane Diallo; Heike Jacobi; Tanja Schmitz-Hübsch; Arron Cook; Robyn Labrum; Alexandra Durr; Alexis Brice; Perrine Charles; Cecilia Marelli; Caterina Mariotti; Lorenzo Nanetti; Marta Panzeri; Maria Rakowicz; Anna Sobanska; Anna Sulek; Ludger Schöls; Holger Hengel; Bela Melegh; Alessandro Filla; Antonella Antenora; Jon Infante; José Berciano; Bart P van de Warrenburg; Dagmar Timmann; Sylvia Boesch; Massimo Pandolfo; Jörg B Schulz; Peter Bauer; Paola Giunti; Laszlo Baliko; Michael H Parkinson; Jun-Suk Kang; Thomas Klockgether; Sophie Tezenas du Montcel Journal: Mov Disord Clin Pract Date: 2017-08-11