H B Cho1, H J Kwak, S Y Park, J Y Kim. 1. Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Korea.
Abstract
BACKGROUND: Intravenous administration of fentanyl derivatives can induce cough paradoxically. This study examined the incidence and severity of cough after a bolus of alfentanil and remifentanil. METHODS: Four hundred and sixty-five patients, aged 18-70 years, were allocated randomly to three groups to receive alfentanil 10 microg/kg, remifentanil 1 microg/kg or an equal volume of 0.9% saline intravenously over 10 s. Any episode of cough was classified as coughing and graded as mild (1-2), moderate (3-4) or severe (5 or more). RESULTS: The overall incidence of cough was higher in the opioid groups than in the saline group. The remifentanil group [39/150 patients; 26.0% (95% CI, 19.6-33.6%)] showed a higher incidence than the alfentanil group [11/152 patients; 7.2% (95% CI, 0.4-12.6%)] (P<0.001). There was no significant difference in the severity of cough between the alfentanil group and the remifentanil group. CONCLUSION: This study demonstrated that equipotent boluses of alfentanil and remifentanil induced coughing, even though the incidence of cough after alfentanil administration was lower than that after remifentanil administration.
RCT Entities:
BACKGROUND: Intravenous administration of fentanyl derivatives can induce cough paradoxically. This study examined the incidence and severity of cough after a bolus of alfentanil and remifentanil. METHODS: Four hundred and sixty-five patients, aged 18-70 years, were allocated randomly to three groups to receive alfentanil 10 microg/kg, remifentanil 1 microg/kg or an equal volume of 0.9% saline intravenously over 10 s. Any episode of cough was classified as coughing and graded as mild (1-2), moderate (3-4) or severe (5 or more). RESULTS: The overall incidence of cough was higher in the opioid groups than in the saline group. The remifentanil group [39/150 patients; 26.0% (95% CI, 19.6-33.6%)] showed a higher incidence than the alfentanil group [11/152 patients; 7.2% (95% CI, 0.4-12.6%)] (P<0.001). There was no significant difference in the severity of cough between the alfentanil group and the remifentanil group. CONCLUSION: This study demonstrated that equipotent boluses of alfentanil and remifentanil induced coughing, even though the incidence of cough after alfentanil administration was lower than that after remifentanil administration.
Authors: Thierry N Boellaard; Marije P van der Paardt; Susanne Eberl; Markus W Hollmann; Jaap Stoker Journal: BMC Gastroenterol Date: 2011-11-23 Impact factor: 3.067
Authors: Thierry N Boellaard; Marije P van der Paardt; Markus W Hollmann; Susanne Eberl; Jan Peringa; Lex J Schouten; Giedre Kavaliauskiene; Jurgen H Runge; Jeroen A W Tielbeek; Jaap Stoker Journal: BMC Gastroenterol Date: 2013-05-25 Impact factor: 3.067
Authors: Venkatesan Thiruvenkatarajan; David T Wong; Harikrishnan Kothandan; Vimal Sekhar; Sanjib Das Adhikary; John Currie; Roelof M Van Wijk Journal: Anesth Analg Date: 2020-09 Impact factor: 6.627